The multi-faceted role of Gata3 in developmental haematopoiesis

The transcription factor Gata3 is crucial for the development of several tissues and cell lineages both during development as well as postnatally. This importance is apparent from the early embryonic lethality following germline Gata3 deletion, with embryos displaying a number of phenotypes, and fro...

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Bibliographic Details
Published in:Open biology 2018-11, Vol.8 (11), p.180152
Main Authors: Zaidan, Nada, Ottersbach, Katrin
Format: Article
Language:English
Subjects:
Animals
development
Embryo, Mammalian - cytology
Embryo, Mammalian - embryology
gata3
GATA3 Transcription Factor - genetics
GATA3 Transcription Factor - metabolism
haematopoiesis
Hematopoiesis - physiology
Hematopoietic Stem Cells - cytology
Hematopoietic Stem Cells - metabolism
Humans
Review
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Summary:The transcription factor Gata3 is crucial for the development of several tissues and cell lineages both during development as well as postnatally. This importance is apparent from the early embryonic lethality following germline Gata3 deletion, with embryos displaying a number of phenotypes, and from the fact that Gata3 has been implicated in several cancer types. It often acts at the level of stem and progenitor cells in which it controls the expression of key lineage-determining factors as well as cell cycle genes, thus being one of the main drivers of cell fate choice and tissue morphogenesis. Gata3 is involved at various stages of haematopoiesis both in the adult as well as during development. This review summarizes the various contributions of Gata3 to haematopoiesis with a particular focus on the emergence of the first haematopoietic stem cells in the embryo-a process that appears to be influenced by Gata3 at various levels, thus highlighting the complex nature of Gata3 action.
ISSN:2046-2441
2046-2441
DOI:10.1098/rsob.180152