Microwave assisted one pot synthesis of 2-alkyl amino benzimidazoles, 2-alkyl amino benzoxazoles and 2-alkyl amino benzthiazoles by using various carbodiimides

[Display omitted] •An array of 2-amino substituted benzimidazole, benzoxazole and benzthiazoles has been synthesized in one step.•Reported large number of compounds with excellent yields.•This methodology offers features like reduced reaction timings.•Atom economy, eco-friendly and reduction in cata...

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Bibliographic Details
Published in:Results in Chemistry 2022-01, Vol.4, p.100351, Article 100351
Main Authors: Rapolu, Thirupathi, Naveen, Polkam, Pavan Kumar, K.V.P., Reddy Leleti, Krishnakanth, korapolu, Raghubabu
Format: Article
Language:English
Subjects:
2-aminobenzimidazole
2-aminobenzoxazole
2-aminobenzthiazole
Bioisosteres
Carbodiimide
Microwave irradiation technique
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Summary:[Display omitted] •An array of 2-amino substituted benzimidazole, benzoxazole and benzthiazoles has been synthesized in one step.•Reported large number of compounds with excellent yields.•This methodology offers features like reduced reaction timings.•Atom economy, eco-friendly and reduction in catalyst toxicity.•Superiority of microwave irradiation technique over conventional methods. A library of bioisosteres namely 2-amino substituted benzimidazole, 2-amino substituted benzoxazole, 2-amino substituted benzthiazole derivatives has been synthesized by an efficient ligand free, zinc catalysed one-pot cascade microwave irradiation technique has been developed. The procedure starts with coupling of various carbodiimides with appropriately substituted o-phenylendiamine, o-aminophenol, o-aminothiols to give the corresponding derivatives in excellent yields.
ISSN:2211-7156
2211-7156
DOI:10.1016/j.rechem.2022.100351