Paroxetine ameliorates changes in hippocampal energy metabolism in chronic mild stress-exposed rats

The molecular mechanisms underlying stress-induced depression have not been fully outlined. Hence, the current study aimed at testing the link between behavioral changes in chronic mild stress (CMS) model and changes in hippocampal energy metabolism and the role of paroxetine (PAROX) in ameliorating...

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Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2015, Vol.11 (default), p.2887-2901
Main Authors: Khedr, Lobna H, Nassar, Noha N, El-Denshary, Ezzeldin S, Abdel-Tawab, Ahmed M
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Antidepressants
Apoptosis
Brain research
Corticosterone
Depression, Mental
Drug therapy
Laboratory animals
Memory
Mental depression
Metabolism
Mitochondria
Neurogenesis
Nitric oxide
Original Research
Pharmacology
Pharmacy
Physiological aspects
Rodents
Stress
Sucrose
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Summary:The molecular mechanisms underlying stress-induced depression have not been fully outlined. Hence, the current study aimed at testing the link between behavioral changes in chronic mild stress (CMS) model and changes in hippocampal energy metabolism and the role of paroxetine (PAROX) in ameliorating these changes. Male Wistar rats were divided into three groups: vehicle control, CMS-exposed rats, and CMS-exposed rats receiving PAROX (10 mg/kg/day intraperitoneally). Sucrose preference, open-field, and forced swimming tests were carried out. Corticosterone (CORT) was measured in serum, while adenosine triphosphate and its metabolites, cytosolic cytochrome-c (Cyt-c), caspase-3 (Casp-3), as well as nitric oxide metabolites (NOx) were measured in hippocampal tissue homogenates. CMS-exposed rats showed a decrease in sucrose preference as well as body weight compared to control, which was reversed by PAROX. The latter further ameliorated the CMS-induced elevation of CORT in serum (91.71±1.77 ng/mL vs 124.5±4.44 ng/mL, P
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/NDT.S87089