Non-alcoholic fatty liver disease is an influencing factor for the association of SHBG with metabolic syndrome in diabetes patients

Metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) have been identified as risk factors affecting serum sex hormone binding globulin (SHBG) levels. We conducted this cross-sectional study to delineate whether MS or NAFLD has more impact on circulating SHBG levels in type 2 diabete...

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Bibliographic Details
Published in:Scientific reports 2017-11, Vol.7 (1), p.14532-7, Article 14532
Main Authors: Hua, Xiaomin, Li, Man, Pan, Fenghui, Xiao, Yunyun, Cui, Wenxia, Hu, Yun
Format: Article
Language:English
Subjects:
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Alcohol use
Androgens
Case-Control Studies
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Fatty liver
Female
Globulins
Humanities and Social Sciences
Humans
Insulin
Lipids
Liver diseases
Male
Metabolic disorders
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Middle Aged
multidisciplinary
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - complications
Regression analysis
Retrospective Studies
Risk factors
Science
Science (multidisciplinary)
Sex Hormone-Binding Globulin - analysis
Smoking
Testosterone
Testosterone - blood
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Summary:Metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) have been identified as risk factors affecting serum sex hormone binding globulin (SHBG) levels. We conducted this cross-sectional study to delineate whether MS or NAFLD has more impact on circulating SHBG levels in type 2 diabetes (T2D) patients. Anthropometric and biochemical parameters including serums SHBG, testosterone (TT), liver enzymes, lipids, insulin, C-peptide and plasma glucose were measured. Regardless of the MS status, SHBG level was significantly lower in NAFLD patients than in non-NAFLD patients ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-15232-9