Biomolecular Condensates Decipher Molecular Codes of Cell Fate: From Biophysical Fundamentals to Therapeutic Practices

Cell fate is precisely modulated by complex but well-tuned molecular signaling networks, whose spatial and temporal dysregulation commonly leads to hazardous diseases. Biomolecular condensates (BCs), as a newly emerging type of biophysical assemblies, decipher the molecular codes bridging molecular...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-04, Vol.25 (7), p.4127
Main Authors: Sun, Xing, Zhou, Yangyang, Wang, Zhiyan, Peng, Menglan, Wei, Xianhua, Xie, Yifang, Wen, Chengcai, Liu, Jing, Ye, Mao
Format: Article
Language:English
Subjects:
Amino acids
Biology
Biomolecular Condensates
Biophysics
Brownian motion
Cell Differentiation
cell fate
Contact angle
Cytoskeleton
diseases
Health aspects
molecular behavior
Motility
Phenotype
physical trait
Physiology
Proteins
Signal Transduction
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Summary:Cell fate is precisely modulated by complex but well-tuned molecular signaling networks, whose spatial and temporal dysregulation commonly leads to hazardous diseases. Biomolecular condensates (BCs), as a newly emerging type of biophysical assemblies, decipher the molecular codes bridging molecular behaviors, signaling axes, and clinical prognosis. Particularly, physical traits of BCs play an important role; however, a panoramic view from this perspective toward clinical practices remains lacking. In this review, we describe the most typical five physical traits of BCs, and comprehensively summarize their roles in molecular signaling axes and corresponding major determinants. Moreover, establishing the recent observed contribution of condensate physics on clinical therapeutics, we illustrate next-generation medical strategies by targeting condensate physics. Finally, the challenges and opportunities for future medical development along with the rapid scientific and technological advances are highlighted.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25074127