Influence of circle of Willis modeling on hemodynamic parameters in anterior communicating artery aneurysms and recommendations for model selection

Computational fluid dynamics (CFD) has been utilized to calculate hemodynamic parameters in anterior communicating artery aneurysm (AComA), which is located at a junction between left and right A1 and A2 segments. However, complete or half circle of Willis (CoW) models are used indiscriminately. Thi...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2024-04, Vol.14 (1), p.8476-8476, Article 8476
Main Authors: Yang, Hyeondong, Cho, Kwang-Chun, Hong, Ineui, Kim, Yeonwoo, Kim, Yong Bae, Kim, Jung-Jae, Oh, Je Hoon
Format: Article
Language:English
Subjects:
639/166/988
692/617/375/1370/534
Aneurysm
Aneurysms
Anterior communicating artery aneurysms
Blood flow
Cerebral blood flow
Circle of Willis
Computational fluid dynamics
Computational neuroscience
Fluid dynamics
Hemodynamic parameters
Hemodynamics
Humanities and Social Sciences
Hydrodynamics
multidisciplinary
Science
Science (multidisciplinary)
Shear stress
Vascular resistance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Computational fluid dynamics (CFD) has been utilized to calculate hemodynamic parameters in anterior communicating artery aneurysm (AComA), which is located at a junction between left and right A1 and A2 segments. However, complete or half circle of Willis (CoW) models are used indiscriminately. This study aims to suggest recommendations for determining suitable CoW model. Five patient-specific CoW models with AComA were used, and each model was divided into complete, left-half, and right-half models. After validating the CFD using a flow experiment, the hemodynamic parameters and flow patterns in five AComAs were compared. In four out of five cases, inflow from one A1 side had a dominant influence on the AComA, while both left and right A1 sides affected the AComA in the remaining case. Also, the average difference in time-averaged wall shear stress between the complete and half models for four cases was 4.6%, but it was 62% in the other case. The differences in the vascular resistances of left and right A1 and A2 segments greatly influenced the flow patterns in the AComA. These results may help to enhance clinicians’ understanding of blood flow in the brain, leading to improvements in diagnosis and treatment of cerebral aneurysms.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-59042-2