Critical review of aging clocks and factors that may influence the pace of aging

Background and objectivesAging clocks are computational models designed to measure biological age and aging rate based on age-related markers including epigenetic, proteomic, and immunomic changes, gut and skin microbiota, among others. In this narrative review, we aim to discuss the currently avail...

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Bibliographic Details
Published in:Frontiers in aging 2024-12, Vol.5
Main Authors: Mildred Min, Caitlin Egli, Ajay S. Dulai, Raja K. Sivamani
Format: Article
Language:English
Subjects:
aging
biological age
clock
epigenetic
microbiome
PACE
Online Access:Get full text
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Summary:Background and objectivesAging clocks are computational models designed to measure biological age and aging rate based on age-related markers including epigenetic, proteomic, and immunomic changes, gut and skin microbiota, among others. In this narrative review, we aim to discuss the currently available aging clocks, ranging from epigenetic aging clocks to visual skin aging clocks.MethodsWe performed a literature search on PubMed/MEDLINE databases with keywords including: “aging clock,” “aging,” “biological age,” “chronological age,” “epigenetic,” “proteomic,” “microbiome,” “telomere,” “metabolic,” “inflammation,” “glycomic,” “lifestyle,” “nutrition,” “diet,” “exercise,” “psychosocial,” and “technology.”ResultsNotably, several CpG regions, plasma proteins, inflammatory and immune biomarkers, microbiome shifts, neuroimaging changes, and visual skin aging parameters demonstrated roles in aging and aging clock predictions. Further analysis on the most predictive CpGs and biomarkers is warranted. Limitations of aging clocks include technical noise which may be corrected with additional statistical techniques, and the diversity and applicability of samples utilized.ConclusionAging clocks have significant therapeutic potential to better understand aging and the influence of chronic inflammation and diseases in an expanding older population.
ISSN:2673-6217
DOI:10.3389/fragi.2024.1487260