Early and late effects of therapeutic plasma exchange in patients with systemic lupus erythematosus and antineutrophil cytoplasmic antibody-associated vasculitis : a single-center experience

• Published in: Saudi journal of kidney diseases and transplantation 2019-07, Vol.30 (4), p.775-780
• Main Authors: Al Hamzi, Hanan, Al-Mayouf, Sulaiman, Al Shaikh, Ahmad, Al-Sheikh, Haifa, Alshomar, Ahmad, Al Humaidan, Hind, Al Dalaan, Abdullah, Al Saleh, Salman
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - blood; Acute Kidney Injury - diagnosis; Acute Kidney Injury - immunology; Acute Kidney Injury - therapy; Adult; Age; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - blood; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - diagnosis; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - therapy; Antibodies; Antibodies, Antineutrophil Cytoplasmic - blood; Apheresis; Autoimmune diseases; Biomarkers - blood; Biopsy; Care and treatment; Complications and side effects; Creatinine - blood; Disease; Female; Glomerular Filtration Rate; Hemorrhage; Humans; Laboratories; Lupus; Lupus erythematosus; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - therapy; Male; Medical research; Middle Aged; Patients; Plasma exchange (Therapeutics); Plasma Exchange - adverse effects; Plasmapheresis; Proteinuria - blood; Proteinuria - immunology; Proteinuria - therapy; Response rates; Retrospective Studies; Risk factors; Saudi Arabia; Sediments; Systemic lupus erythematosus; Therapeutics; Time Factors; Treatment Outcome; Urine; Vasculitis; التهاب الأوعية; الذئبة الحمامية; المرضى; المضاعفات
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.265452

Therapeutic plasma exchanges (TPE) is considered as one of the treatment modalities that is used in systemic autoimmune diseases. This study aimed to describe the early and late effect of TPE in patients with systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) presented with acute kidney injury (AKI). Retrospective study comprised patients with SLE and AAV with AKI seen between January 2000 and June 2014 at King Faisal Specialist Hospital and Research Center in Riyadh. All patients underwent TPE. Retrospectively, all patients were assessed for early and late renal outcome at 12- month and 24-month intervals. Renal outcome was assessed according to serum creatinine level, glomerular filtration rate, active urine sediment, and proteinuria. P