Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations

Days ago, the Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation". This news has increased the attention on immunotoxicity and immune evasion mechanisms, whic...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-10, Vol.19 (11), p.3307
Main Authors: Wu, Qinghua, Wu, Wenda, Franca, Tanos C C, Jacevic, Vesna, Wang, Xu, Kuca, Kamil
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Autophagy
Biochemistry
Cancer
Conflicts of interest
Gene expression
Humans
Immune Evasion
Immune system
Immunoregulation
Immunosuppression
Immunosuppressive Agents - pharmacology
Immunosuppressive Agents - therapeutic use
Immunotoxicity
Molecular biology
Mycotoxins
negative immune regulations
Nobel prizes
Oxidative stress
Pathogens
Physiology
T-2 toxin
Toxicology
Toxins
Trichothecenes
Trichothecenes - pharmacology
Trichothecenes - therapeutic use
Tumors
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Summary:Days ago, the Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation". This news has increased the attention on immunotoxicity and immune evasion mechanisms, which are once again hot research topics. Actually, increasing lines of evidence show that trichothecene mycotoxins have a strong immunosuppressive effect. These mycotoxins suppress the host immunity and make them more sensitive to the infection of pathogens, including bacteria and viruses. However, the underlying mechanism(s) in this context is still poorly understood. Interestingly, recent work showed that an immune evasion mechanism might be involved in trichothecene immunotoxicity. In this work, we discuss the potential immune evasion mechanism in trichothecene immunotoxicity. More importantly, under these circumstances, we are pleased to compile a Special Issue entitled "Biochemistry, Molecular Biology, and Toxicology of Natural and Synthetic Toxins" for the ( ). Researchers are encouraged to share their latest interesting findings with the readers of .
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19113307