Effect of different types of stress on adrenal gland parameters and adrenal hormones in the blood serum of male Wistar rats

In the present study, we examined gross changes in the mass of whole adrenal glands and that of the adrenal cortex and medulla in mature male Wistar rats subjected to three different stress types: acute, chronic, and combined, i.e., chronic followed by acute stress. Under of three conditions, we obs...

Full description

Saved in:
Bibliographic Details
Published in:Archives of biological sciences 2009, Vol.61 (2), p.187-194
Main Authors: Adzic, M, Djordjevic, A, Djordjevic, J, Niciforovic, A, Radojcic, M.B., Vinca Institute of Nuclear Sciences, Belgrade (Serbia). Laboratory of Molecular Biology and Endocrinology
Format: Article
Language:English
Subjects:
ADRENAL CORTEX HORMONES
ADRENAL GLANDS
adrenal hormones
AISLAMIENTO
ESTRES
GLANDULAS SUPRARRENALES
HORMONAS SUPRARRENALES
HORMONE CORTICOSURRENALE
http://www.fao.org/aos/agrovoc#c_134
http://www.fao.org/aos/agrovoc#c_135
http://www.fao.org/aos/agrovoc#c_27550
http://www.fao.org/aos/agrovoc#c_37744
http://www.fao.org/aos/agrovoc#c_6464
http://www.fao.org/aos/agrovoc#c_7452
IMMOBILISATION
IMMOBILIZATION
INMOVILIZACION
ISOLATION
ISOLEMENT
RAT
RATA
RATS
STRESS
SURRENALE
Wistar rats
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the present study, we examined gross changes in the mass of whole adrenal glands and that of the adrenal cortex and medulla in mature male Wistar rats subjected to three different stress types: acute, chronic, and combined, i.e., chronic followed by acute stress. Under of three conditions, we observed bilaterally asymmetric and stress-type-independent hypertrophy of whole adrenals, as well as adrenal cortices and medullas. Under acute and combined stress, adrenal hypertrophy was followed by increase of adrenal hormones in the blood serum. However, under chronic stress, both cortical and medullar activities as judged from low or unaltered levels of the respectives hormones and glucose were compromised and disconnected from the input signal of ACTH. Since all of the studied adrenal activities could be restored by subsequent acute stress, it is concluded that chonic isolation can be viewed as partly maladaptive stress with characteristics resembling stress resistance rather than the stress exhaustion stage of the general adaptation syndrome.
ISSN:0354-4664
1821-4339
DOI:10.2298/ABS0902187A