Ivermectin reduces in vivo coronavirus infection in a mouse experimental model

The objective of this study was to test the effectiveness of ivermectin for the treatment of mouse hepatitis virus (MHV), a type 2 family RNA coronavirus similar to SARS-CoV-2. Female BALB/cJ mice were infected with 6,000 PFU of MHV-A59 (group infected, n = 20) or infected and then immediately treat...

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Bibliographic Details
Published in:Scientific reports 2021-03, Vol.11 (1), p.7132-7132, Article 7132
Main Authors: Arévalo, A. P., Pagotto, R., Pórfido, J. L., Daghero, H., Segovia, M., Yamasaki, K., Varela, B., Hill, M., Verdes, J. M., Duhalde Vega, M., Bollati-Fogolín, M., Crispo, M.
Format: Article
Language:English
Subjects:
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Alanine
Alanine transaminase
Animals
Antiviral Agents - administration & dosage
Antiviral Agents - pharmacology
Aspartate aminotransferase
Body Weight - drug effects
Coronaviridae
Coronavirus Infections - drug therapy
Coronavirus Infections - pathology
Coronavirus Infections - virology
Coronaviruses
COVID-19
Disease Models, Animal
Female
Hepatitis
Humanities and Social Sciences
Infections
Inflammation
Ivermectin
Ivermectin - administration & dosage
Ivermectin - pharmacology
Kidney - drug effects
Kidney - metabolism
Liver - drug effects
Liver - metabolism
Liver - pathology
Liver - virology
Mice
Mice, Inbred BALB C
Monocytes - drug effects
multidisciplinary
Murine hepatitis virus - pathogenicity
Neutrophils - drug effects
Proteins - metabolism
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Transaminase
Transaminases - metabolism
Tumor Necrosis Factor-alpha - blood
Viral infections
Viral Load - drug effects
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Summary:The objective of this study was to test the effectiveness of ivermectin for the treatment of mouse hepatitis virus (MHV), a type 2 family RNA coronavirus similar to SARS-CoV-2. Female BALB/cJ mice were infected with 6,000 PFU of MHV-A59 (group infected, n = 20) or infected and then immediately treated with a single dose of 500 µg/kg ivermectin (group infected + IVM, n = 20) or were not infected and treated with PBS (control group, n = 16). Five days after infection/treatment, the mice were euthanized and the tissues were sampled to assess their general health status and infection levels. Overall, the results demonstrated that viral infection induced typical MHV-caused disease, with the livers showing severe hepatocellular necrosis surrounded by a severe lymphoplasmacytic inflammatory infiltration associated with a high hepatic viral load (52,158 AU), while mice treated with ivermectin showed a better health status with a lower viral load (23,192 AU; p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-86679-0