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Serum anti-erythropoietin antibodies among pregnant women with Plasmodium falciparum malaria and anaemia: A case-control study in northern Ghana

Background Anaemia in pregnancy is common in underdeveloped countries, and malaria remains the predominant cause of the condition in Ghana. Anti-erythropoietin (anti-EPO) antibody production may be implicated in the pathogenesis of Plasmodium falciparum malaria-related anaemia in pregnancy. This stu...

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Bibliographic Details
Published in:PloS one 2023-03, Vol.18 (3)
Main Authors: Charles Nkansah, Simon Bannison Bani, Kofi Mensah, Samuel Kwasi Appiah, Felix Osei-Boakye, Gabriel Abbam, Samira Daud, Eugene Mensah Agyare, Peace Esenam Agbadza, Charles Angnataa Derigubah, Dorcas Serwaa, Francis Atoroba Apodola, Yeduah Quansah, Rahama Issah, Samuel Yennuloom Dindiok, Felix Ejike Chukwurah
Format: Article
Language:English
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Summary:Background Anaemia in pregnancy is common in underdeveloped countries, and malaria remains the predominant cause of the condition in Ghana. Anti-erythropoietin (anti-EPO) antibody production may be implicated in the pathogenesis of Plasmodium falciparum malaria-related anaemia in pregnancy. This study ascertained the prevalence of anti-EPO antibody production and evaluated the antibodies’ relationship with Plasmodium falciparum malaria and malaria-related anaemia in pregnancy. Methods This hospital-based case-control study recruited a total of 85 pregnant women (55 with Plasmodium falciparum malaria and 30 controls without malaria). Venous blood was taken from participants for thick and thin blood films for malaria parasite microscopy. Complete blood count (CBC) analyses were done using an automated haematology analyzer. Sandwich enzyme-linked immunosorbent assay (ELISA) was used to assess serum erythropoietin (EPO) levels and anti-EPO antibodies. Data were analyzed using IBM SPSS version 22.0. Results Haemoglobin (p
ISSN:1932-6203
DOI:10.1371/journal.pone.0283427