Bisphenol A, S or F mother’s dermal impregnation impairs offspring immune responses in a dose and sex-specific manner in mice

Bisphenol (BP)A is an endocrine disruptor (ED) widely used in thermal papers. Regulatory restrictions have been established to prevent risks for human health, leading to BPA substitution by structural analogues, like BPS and BPF. We previously demonstrated that oral perinatal exposure to BPA had lon...

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.1650-1650, Article 1650
Main Authors: Malaisé, Yann, Lencina, Corinne, Cartier, Christel, Olier, Maïwenn, Ménard, Sandrine, Guzylack-Piriou, Laurence
Format: Article
Language:English
Subjects:
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Bisphenol A
Body weight
Endocrine disruptors
Food and Nutrition
Gestation
Humanities and Social Sciences
Immune response
Immune system
Intestine
Life Sciences
multidisciplinary
Offspring
Perinatal exposure
Risk assessment
Science
Science (multidisciplinary)
Sex
Skin
Toxicology
Toxicology and food chain
Weaning
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Summary:Bisphenol (BP)A is an endocrine disruptor (ED) widely used in thermal papers. Regulatory restrictions have been established to prevent risks for human health, leading to BPA substitution by structural analogues, like BPS and BPF. We previously demonstrated that oral perinatal exposure to BPA had long-term consequences on immune responses later in life. It appears now essential to enhance our understanding on immune impact of different routes of BP exposure. In this study, we aimed at comparing the impact of mother dermal exposure to BPs on offspring immune system at adulthood. Gravid mice were dermally exposed to BPA, BPS or BPF at 5 or 50 μg/kg of body weight (BW)/day (d) from gestation day 15 to weaning of pups at post-natal day (PND)21. In offspring, BPs dermal impregnation of mothers led to adverse effects on immune response at intestinal and systemic levels that was dependent on the BP, the dose and offspring sex. These findings provide, for the first time, results on long-term consequences of dermal perinatal BPs exposure on immune responses in offspring. This work warns that it is mandatory to consider immune markers, dose exposure as well as sex in risk assessment associated with new BPA’s alternatives.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-81231-6