Rapid Cerebral Metabolic Shift during Neonatal Sepsis Is Attenuated by Enteral Colostrum Supplementation in Preterm Pigs

Sepsis, the clinical manifestation of serious infection, may disturb normal brain development, especially in preterm infants with an immature brain. We hypothesized that neonatal sepsis induces systemic metabolic alterations that rapidly affect metabolic signatures in immature brain and cerebrospina...

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Bibliographic Details
Published in:Metabolites 2019-01, Vol.9 (1), p.13
Main Authors: Alinaghi, Masoumeh, Jiang, Ping-Ping, Brunse, Anders, Sangild, Per Torp, Bertram, Hanne Christine
Format: Article
Language:English
Subjects:
Alanine
Animals
bioactive dairy components
Birth weight
bloodstream infection
brain metabolites
cerebral metabolism
Cerebrospinal fluid
Colostrum
Data analysis
Dietary supplements
Energy metabolism
enteral feeding
Gene expression
Hogs
Infants
Inflammation
Inositol
Lactic acid
Medical technology
Metabolism
Metabolites
Metabolomics
neonatal sepsis
Neonates
Newborn babies
NMR
NMR metabolomics
Nosocomial infections
Nuclear magnetic resonance
Nutrition
Parenteral nutrition
Plasma
Premature babies
preterm infants
Sepsis
Spectrum analysis
Staphylococcus epidermidis
Traumatic brain injury
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Summary:Sepsis, the clinical manifestation of serious infection, may disturb normal brain development, especially in preterm infants with an immature brain. We hypothesized that neonatal sepsis induces systemic metabolic alterations that rapidly affect metabolic signatures in immature brain and cerebrospinal fluid (CSF). Cesarean-delivered preterm pigs systemically received 10⁸ CFU/kg (SE) and were provided total parenteral nutrition ( = 9) or enteral supplementation with bovine colostrum ( = 10) and compared with uninfected pigs receiving parenteral nutrition ( = 7). Plasma, CSF, and brain tissue samples were collected after 24 h and analyzed by ¹H NMR-based metabolomics. Both plasma and CSF metabolomes revealed SE-induced changes in metabolite levels that reflected a modified energy metabolism. Hence, increased plasma lactate, alanine, and succinate levels, as well as CSF lactate levels, were observed during SE infection (all < 0.05, ANOVA analysis). -inositol, a glucose derivative known for beneficial effects on lung maturation in preterm infants, was also increased in plasma and CSF following SE infection. Enteral colostrum supplementation attenuated the lactate accumulation in blood and CSF. Bloodstream infection in preterm newborns was found to induce a rapid metabolic shift in both plasma and CSF, which was modulated by colostrum feeding.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo9010013