Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man

To examine the possible age-related blood pressure (BP) deregulation in response to central hypervolemia, we measured spontaneous baroreflex sensitivity (SBRS), carotid arterial compliance (CC), and R-R interval coefficient of variation (RRICV) during basal and thermoneutral resting head-out-of-wate...

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Bibliographic Details
Published in:Brazilian journal of medical and biological research 2005-04, Vol.38 (4), p.629-637
Main Authors: Ueno, L M, Miyachi, M, Matsui, T, Takahashi, K, Yamazaki, K, Hayashi, K, Onodera, S, Moritani, T
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aging
Aging - physiology
Baroreflex - physiology
Baroreflex sensitivity
BIOLOGY
Blood Pressure - physiology
Carotid Arteries - anatomy & histology
Carotid Arteries - physiology
Carotid compliance
Electrocardiography
Heart Rate - physiology
Humans
Hypertension
Hypovolemia
Immersion
Male
MEDICINE, RESEARCH & EXPERIMENTAL
Middle Aged
Rest - physiology
Vascular stiffness
Water immersion
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Summary:To examine the possible age-related blood pressure (BP) deregulation in response to central hypervolemia, we measured spontaneous baroreflex sensitivity (SBRS), carotid arterial compliance (CC), and R-R interval coefficient of variation (RRICV) during basal and thermoneutral resting head-out-of-water immersion (HOWI) in 7 young (YG = 24.0 +/- 0.8 years) and 6 middle-aged/older (OL = 59.3 +/- 1.3 years) healthy men. Compared with basal conditions (YG = 19.6 +/- 4.0 vs OL = 6.1 +/- 1.5 ms/mmHg, P < 0.05), SBRS remained higher in YG than OL during rest HOWI (YG = 23.6 +/- 6.6 vs OL = 9.3 +/- 2.1 ms/mmHg, P < 0.05). The RRICV was significantly different between groups (YG = 6.5 +/- 1.4 vs OL = 2.8 +/- 0.4%, P < 0.05) under HOWI. The OL group had no increase in CC, but a significant increase in systolic BP (basal = 115.3 +/- 4.4 vs water = 129.3 +/- 5.3 mmHg, P < 0.05) under HOWI. In contrast, the YG group had a significant increase in CC (basal = 0.16 +/- 0.01 vs water = 0.17 +/- 0.02 mm(2)/mmHg, P < 0.05) with no changes in systolic BP. SBRS was positively related to CC (r = 0.58, P < 0.05 for basal vs r = 0.62, P < 0.05 for water). Our data suggest that age-related vagal dysfunction and reduced CC may be associated with SBRS differences between YG and OL groups, and with BP elevation during HOWI in healthy older men.
ISSN:0100-879X
1414-431X
0100-879X
0034-7310
DOI:10.1590/s0100-879x2005000400018