In silico functional annotation of a hypothetical protein from Staphylococcus aureus

Summary Unknown proteins or hypothetical proteins exist but have not been characterized or linked to known genes. Domains of unknown function are experimentally identified proteins with no known functional or structural domain. In this paper, the investigation and characterization of the likely func...

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Bibliographic Details
Published in:Journal of infection and public health 2015-11, Vol.8 (6), p.526-532
Main Authors: Bharat Siva Varma, P, Adimulam, Yesu B, Kodukula, Subrahmaniam
Format: Article
Language:English
Subjects:
Bacterial Proteins - genetics
Blast
Computational Biology
Domains of unknown function
HHpred
Hypothetical protein
Infectious Disease
Internal Medicine
Molecular Sequence Annotation
Protein Binding
Protein Structure, Tertiary
Staphylococcus aureus - genetics
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Summary:Summary Unknown proteins or hypothetical proteins exist but have not been characterized or linked to known genes. Domains of unknown function are experimentally identified proteins with no known functional or structural domain. In this paper, the investigation and characterization of the likely functional aspects of a hypothetical protein, YP_001317347.1, from Staphylococcus aureus was performed using various computational methods and tools. Based on the analysis, the protein has a YbbR domain and is expected to bind ribosomal subunits. The analysis reported here helps in understanding the importance of YbbR domains and will aid in the development of novel antibacterial agents.
ISSN:1876-0341
1876-035X
DOI:10.1016/j.jiph.2015.03.007