Antimutagenic effect of resveratrol

Evidence exists from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity. We studied the protective effect of the plant phytoallexin resveratrol on the mutagenic activity of three mutagens, i.e. a...

Full description

Saved in:
Bibliographic Details
Published in:Czech Journal of Food Sciences 2005, Vol.23 (5), p.202-208
Main Authors: Langová, Martina, Polívková, Zdeňka, Šmerák, Petr, Bártová, Jiřina, Bárta, Ivo
Format: Article
Language:English
Subjects:
2-amino-3-methylimidazo[4,5-f]quinoline
Aflatoxin B1
Aflatoxins
Ames test
Anticancer properties
Intelligence
Mutagenicity
Mutagens
N-Methyl-N-nitrosourea
n-nitroso-n-methylurea
Population studies
Resveratrol
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Evidence exists from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity. We studied the protective effect of the plant phytoallexin resveratrol on the mutagenic activity of three mutagens, i.e. aflatoxin B1 (AFB1), 2-amino-3-methylimidazo[4,5-f]qui-noline (IQ) and N-nitroso-N-methylurea (MNU) using the Ames and the micronucleus tests. In the Ames test, we proved a significant antimutagenic activity only against the indirect mutagens AFB1 and IQ, not against the direct mutagen MNU. A significant decrease of mutagenicity of all three mutagens was detected by the micronucleus test.
ISSN:1212-1800
1805-9317
DOI:10.17221/3392-CJFS