Risk factors for post-cerebral infarction cognitive dysfunction in older adults: a retrospective study

• Published in: BMC neurology 2024-02, Vol.24 (1), p.72-72, Article 72
• Main Authors: Ma, Fanyuan, Zhang, Qian, Li, Jinke, Wu, Liping, Zhang, Hua
• Format: Article
• Language: English
• Subjects: Age groups; Aged; Aged, 80 and over; Bilirubin; Biomarkers; Brain; Cerebral infarction; Cerebral Infarction - complications; Cerebral Infarction - epidemiology; Cognition; Cognition & reasoning; Cognition disorders in old age; Cognitive ability; Cognitive dysfunction; Cognitive Dysfunction - complications; Cognitive Dysfunction - etiology; Complications and side effects; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Education; Executive function; Female; Gender; Humans; Illiteracy; Infarction; Male; Middle schools; Older adults; Older people; Regression analysis; Retrospective Studies; Risk Factors; Rural areas; Stroke; Type 2 diabetes; Variables; Variance analysis
• ISSN: 1471-2377; 1471-2377
• DOI: 10.1186/s12883-024-03574-7

Our research aims to elucidate the significance of type 2 diabetes (T2D) and provides an insight into a novel risk model for post-cerebral infarction cognitive dysfunction (PCICD). Our study recruited inpatients hospitalized with cerebral infarction in Xijing hospital, who underwent cognitive assessment of Mini-Mental State Examination (MMSE) from January 2010 to December 2021. Cognitive status was dichotomized into normal cognition and cognitive impairment. Collected data referred to Demographic Features, Clinical Diseases, scale tests, fluid biomarkers involving inflammation, coagulation function, hepatorenal function, lipid and glycemic management. In our pooled dataset from 924 eligible patients, we included 353 in the final analysis (age range 65-91; 30.31% female). Multivariate logistic regression analysis was performed to show that Rural Areas (OR = 1.976, 95%CI = 1.111-3.515, P = 0.020), T2D (OR = 2.125, 95%CI = 1.267-3.563, P = 0.004), Direct Bilirubin (OR = 0.388, 95%CI = 0.196-0.769, P = 0.007), Severity of Dependence in terms of Barthel Index (OR = 1.708, 95%CI = 1.193-2.445, P = 0.003) that were independently associated with PCICD, constituting a model with optimal predictive efficiency. To the best of our knowledge, this study provides a practicable map of strategical predictors to robustly identify cognitive dysfunction at risk of post-cerebral infarction for clinicians in a broad sense. Of note, our findings support that the decline in serum direct bilirubin (DBil) concentration is linked to protecting cognitive function.