Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

Nanomaterials with bone-mimicking characteristics and easily internalized by the cell could create suitable microenvironments in which to regulate the therapeutic effects of bone regeneration. This review provides an overview of the current state-of-the-art research in developing and using nanomater...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2023-04, Vol.13 (9), p.1449
Main Authors: Wan, Teng, Zhang, Meng, Jiang, Hao-Ran, Zhang, Yi-Chong, Zhang, Xiao-Meng, Wang, Yi-Lin, Zhang, Pei-Xun
Format: Article
Language:English
Subjects:
Analysis
Biomedical materials
Blood vessels
Bone biomaterials
Bone growth
Bone marrow
bone tissue injury
Bones
Care and treatment
Chemical properties
Collagen
drug loading
engineered bone tissue
Engineering
Extracellular matrix
Fractures
Growth factors
Hydroxyapatite
Injuries
Methods
Microenvironments
nanomaterial
Nanomaterials
nanoparticle
Nanotechnology
Physiology
Regeneration
Regeneration (physiology)
Review
Stem cells
Substitute bone
targeted therapy
Tissue engineering
Tumors
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Summary:Nanomaterials with bone-mimicking characteristics and easily internalized by the cell could create suitable microenvironments in which to regulate the therapeutic effects of bone regeneration. This review provides an overview of the current state-of-the-art research in developing and using nanomaterials for better bone injury repair. First, an overview of the hierarchical architecture from the macroscale to the nanoscale of natural bone is presented, as these bone tissue microstructures and compositions are the basis for constructing bone substitutes. Next, urgent clinical issues associated with bone injury that require resolution and the potential of nanomaterials to overcome them are discussed. Finally, nanomaterials are classified as inorganic or organic based on their chemical properties. Their basic characteristics and the results of related bone engineering studies are described. This review describes theoretical and technical bases for the development of innovative methods for repairing damaged bone and should inspire therapeutic strategies with potential for clinical applications.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano13091449