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Mucosal immunity in health care workers’ respiratory tracts in the post-COVID-19 period
Coronavirus disease (COVID-19) has generated interest in the assessment of systemic immune status, but existing knowledge about mucosal immunity is clearly insufficient to understand the full pathogenetic mechanisms of the disease. The aim of this study was to evaluate the long-term effects of novel...
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| Published in: | Scientific reports 2023-05, Vol.13 (1), p.7162-7162, Article 7162 |
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| description | Coronavirus disease (COVID-19) has generated interest in the assessment of systemic immune status, but existing knowledge about mucosal immunity is clearly insufficient to understand the full pathogenetic mechanisms of the disease. The aim of this study was to evaluate the long-term effects of novel coronavirus infection on mucosal immunity in the postinfection period among health care workers (HCWs). A total of 180 health care workers with and without a history of COVID-19 who ranged in age from 18 to 65 years were enrolled in this one-stage, cross-sectional study. The study subjects completed the 36-Item Short Form (36) Health Survey (SF-36) and the Fatigue Assessment Scale. Secretory immunoglobulin A (sIgA) and total immunoglobulin G (IgG) levels were quantified in saliva samples, induced sputum samples, and nasopharyngeal and oropharyngeal scrapings by an enzyme-linked immunosorbent assay. Specific anti-SARS-CoV-2 IgG antibodies were quantified in serum samples by chemiluminescence immunoassay. Analysis of the questionnaire data showed that all HCWs with a history of COVID-19 reported health problems that limited their daily activities and negative changes in their emotional health three months after the disease, regardless of its severity. The following shifts were detected in the adaptive arm of the immune response in different mucosal compartments. Among subjects who had severe or moderate-to-severe COVID-19, salivary sIgA levels were significantly higher than those in the control group (
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| doi_str_mv | 10.1038/s41598-023-32670-w |
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| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_1697a4b52287496885e4baf9a6fd8634</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_1697a4b52287496885e4baf9a6fd8634</doaj_id><sourcerecordid>2809546421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-af3582ee44e23126e99c2dba0260ec66f4b0a4d91c6d0eb6c476b683fa04901b3</originalsourceid><addsrcrecordid>eNp9kstu1DAUhiMEolXpC7BAkdiwCfgee4XQcBupqBtAYmU5zsmMhyQOtsNodrwGr8eT4GlKaVngjS_nP5_Psf-ieIzRc4yofBEZ5kpWiNCKElGjan-vOCWI8YpQQu7fWp8U5zHuUB6cKIbVw-KE1pjKvD8tvnyYrY-mL90wzKNLh9KN5RZMn7alNQHKvQ9fIcRfP36WAeLkgkk-HMoUjE3xKE5bKCcfU7W6_Lx-XWFVThCcbx8VDzrTRzi_ns-KT2_ffFy9ry4u361Xry4qyxlOlekolwSAMSAUEwFKWdI2BhGBwArRsQYZ1ipsRYugEZbVohGSdgYxhXBDz4r1wm292ekpuMGEg_bG6asDHzbahORsDxoLVRvWcEJkzZSQkgNrTKeM6FopKMuslwtrmpsBWgtj7rO_A70bGd1Wb_x3jRHmrOYiE55dE4L_NkNMenDRQt-bEfwcNZFIcSYYwVn69B_pzs9hzG91VMm6pgwdSyKLygYfY4DuphqM9NEJenGCzk7QV07Q-5z05HYfNyl__j0L6CKIOTRuIPy9-z_Y3-Hfvxg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2808773404</pqid></control><display><type>article</type><title>Mucosal immunity in health care workers’ respiratory tracts in the post-COVID-19 period</title><source>PubMed Central Free</source><source>Publicly Available Content Database</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature - nature.com Journals - Fully Open Access</source><creator>Kryukova, Nadezhda ; Baranova, Irina ; Abramova, Natalia ; Khromova, Ekaterina ; Pachomov, Dmitry ; Svitich, Oksana ; Chuchalin, Alexander ; Kostinov, Mikhail</creator><creatorcontrib>Kryukova, Nadezhda ; Baranova, Irina ; Abramova, Natalia ; Khromova, Ekaterina ; Pachomov, Dmitry ; Svitich, Oksana ; Chuchalin, Alexander ; Kostinov, Mikhail</creatorcontrib><description>Coronavirus disease (COVID-19) has generated interest in the assessment of systemic immune status, but existing knowledge about mucosal immunity is clearly insufficient to understand the full pathogenetic mechanisms of the disease. The aim of this study was to evaluate the long-term effects of novel coronavirus infection on mucosal immunity in the postinfection period among health care workers (HCWs). A total of 180 health care workers with and without a history of COVID-19 who ranged in age from 18 to 65 years were enrolled in this one-stage, cross-sectional study. The study subjects completed the 36-Item Short Form (36) Health Survey (SF-36) and the Fatigue Assessment Scale. Secretory immunoglobulin A (sIgA) and total immunoglobulin G (IgG) levels were quantified in saliva samples, induced sputum samples, and nasopharyngeal and oropharyngeal scrapings by an enzyme-linked immunosorbent assay. Specific anti-SARS-CoV-2 IgG antibodies were quantified in serum samples by chemiluminescence immunoassay. Analysis of the questionnaire data showed that all HCWs with a history of COVID-19 reported health problems that limited their daily activities and negative changes in their emotional health three months after the disease, regardless of its severity. The following shifts were detected in the adaptive arm of the immune response in different mucosal compartments. Among subjects who had severe or moderate-to-severe COVID-19, salivary sIgA levels were significantly higher than those in the control group (
p
< 0.05 and
p
< 0.005, respectively). Compared to the subjects in the control group, all subjects with prior COVID-19 had significantly higher levels of total IgG in induced sputum. In the group of patients who had had severe infection, total IgG in saliva was also higher (
p
< 0.05). A direct statistically significant correlation was also detected between the levels of total IgG in all studied samples and the levels of specific IgG antibodies against SARS-CoV-2 in the serum. A significant correlation was observed between total IgG levels and the parameters of physical and social activities, mental health, and fatigue levels. Our study demonstrated long-term changes in the humoral mucosal immune response, which were most pronounced in health care workers with a history of severe or moderate-to-severe COVID-19, and an association of these changes with certain clinical signs of post-COVID-19 syndrome.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-023-32670-w</identifier><identifier>PMID: 37138005</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250 ; 631/250/2152 ; 631/250/254 ; 631/250/347 ; Adult ; Antibodies, Viral - analysis ; Chemiluminescence ; Coronaviruses ; COVID-19 ; COVID-19 - immunology ; COVID-19 - pathology ; COVID-19 - physiopathology ; Enzyme-linked immunosorbent assay ; Fatigue ; Health care ; Health Personnel ; Health problems ; Humanities and Social Sciences ; Humans ; Immune response ; Immune response (humoral) ; Immune status ; Immunity (Disease) ; Immunity, Mucosal ; Immunoglobulin A ; Immunoglobulin A - analysis ; Immunoglobulin G ; Immunoglobulin G - analysis ; Immunoglobulins ; Long-term effects ; Medical personnel ; Middle Aged ; Mucosal immunity ; multidisciplinary ; Respiratory System - immunology ; Respiratory tract ; Russia ; Saliva ; SARS-CoV-2 - physiology ; Science ; Science (multidisciplinary) ; Severe acute respiratory syndrome coronavirus 2 ; Severity of Illness Index ; Sputum ; Statistical analysis ; Young Adult</subject><ispartof>Scientific reports, 2023-05, Vol.13 (1), p.7162-7162, Article 7162</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-af3582ee44e23126e99c2dba0260ec66f4b0a4d91c6d0eb6c476b683fa04901b3</citedby><cites>FETCH-LOGICAL-c541t-af3582ee44e23126e99c2dba0260ec66f4b0a4d91c6d0eb6c476b683fa04901b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2808773404/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2808773404?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37138005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kryukova, Nadezhda</creatorcontrib><creatorcontrib>Baranova, Irina</creatorcontrib><creatorcontrib>Abramova, Natalia</creatorcontrib><creatorcontrib>Khromova, Ekaterina</creatorcontrib><creatorcontrib>Pachomov, Dmitry</creatorcontrib><creatorcontrib>Svitich, Oksana</creatorcontrib><creatorcontrib>Chuchalin, Alexander</creatorcontrib><creatorcontrib>Kostinov, Mikhail</creatorcontrib><title>Mucosal immunity in health care workers’ respiratory tracts in the post-COVID-19 period</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Coronavirus disease (COVID-19) has generated interest in the assessment of systemic immune status, but existing knowledge about mucosal immunity is clearly insufficient to understand the full pathogenetic mechanisms of the disease. The aim of this study was to evaluate the long-term effects of novel coronavirus infection on mucosal immunity in the postinfection period among health care workers (HCWs). A total of 180 health care workers with and without a history of COVID-19 who ranged in age from 18 to 65 years were enrolled in this one-stage, cross-sectional study. The study subjects completed the 36-Item Short Form (36) Health Survey (SF-36) and the Fatigue Assessment Scale. Secretory immunoglobulin A (sIgA) and total immunoglobulin G (IgG) levels were quantified in saliva samples, induced sputum samples, and nasopharyngeal and oropharyngeal scrapings by an enzyme-linked immunosorbent assay. Specific anti-SARS-CoV-2 IgG antibodies were quantified in serum samples by chemiluminescence immunoassay. Analysis of the questionnaire data showed that all HCWs with a history of COVID-19 reported health problems that limited their daily activities and negative changes in their emotional health three months after the disease, regardless of its severity. The following shifts were detected in the adaptive arm of the immune response in different mucosal compartments. Among subjects who had severe or moderate-to-severe COVID-19, salivary sIgA levels were significantly higher than those in the control group (
p
< 0.05 and
p
< 0.005, respectively). Compared to the subjects in the control group, all subjects with prior COVID-19 had significantly higher levels of total IgG in induced sputum. In the group of patients who had had severe infection, total IgG in saliva was also higher (
p
< 0.05). A direct statistically significant correlation was also detected between the levels of total IgG in all studied samples and the levels of specific IgG antibodies against SARS-CoV-2 in the serum. A significant correlation was observed between total IgG levels and the parameters of physical and social activities, mental health, and fatigue levels. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kryukova, Nadezhda</au><au>Baranova, Irina</au><au>Abramova, Natalia</au><au>Khromova, Ekaterina</au><au>Pachomov, Dmitry</au><au>Svitich, Oksana</au><au>Chuchalin, Alexander</au><au>Kostinov, Mikhail</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucosal immunity in health care workers’ respiratory tracts in the post-COVID-19 period</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2023-05-03</date><risdate>2023</risdate><volume>13</volume><issue>1</issue><spage>7162</spage><epage>7162</epage><pages>7162-7162</pages><artnum>7162</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Coronavirus disease (COVID-19) has generated interest in the assessment of systemic immune status, but existing knowledge about mucosal immunity is clearly insufficient to understand the full pathogenetic mechanisms of the disease. The aim of this study was to evaluate the long-term effects of novel coronavirus infection on mucosal immunity in the postinfection period among health care workers (HCWs). A total of 180 health care workers with and without a history of COVID-19 who ranged in age from 18 to 65 years were enrolled in this one-stage, cross-sectional study. The study subjects completed the 36-Item Short Form (36) Health Survey (SF-36) and the Fatigue Assessment Scale. Secretory immunoglobulin A (sIgA) and total immunoglobulin G (IgG) levels were quantified in saliva samples, induced sputum samples, and nasopharyngeal and oropharyngeal scrapings by an enzyme-linked immunosorbent assay. Specific anti-SARS-CoV-2 IgG antibodies were quantified in serum samples by chemiluminescence immunoassay. Analysis of the questionnaire data showed that all HCWs with a history of COVID-19 reported health problems that limited their daily activities and negative changes in their emotional health three months after the disease, regardless of its severity. The following shifts were detected in the adaptive arm of the immune response in different mucosal compartments. Among subjects who had severe or moderate-to-severe COVID-19, salivary sIgA levels were significantly higher than those in the control group (
p
< 0.05 and
p
< 0.005, respectively). Compared to the subjects in the control group, all subjects with prior COVID-19 had significantly higher levels of total IgG in induced sputum. In the group of patients who had had severe infection, total IgG in saliva was also higher (
p
< 0.05). A direct statistically significant correlation was also detected between the levels of total IgG in all studied samples and the levels of specific IgG antibodies against SARS-CoV-2 in the serum. A significant correlation was observed between total IgG levels and the parameters of physical and social activities, mental health, and fatigue levels. Our study demonstrated long-term changes in the humoral mucosal immune response, which were most pronounced in health care workers with a history of severe or moderate-to-severe COVID-19, and an association of these changes with certain clinical signs of post-COVID-19 syndrome.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>37138005</pmid><doi>10.1038/s41598-023-32670-w</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 2045-2322 2045-2322 |
| language | eng |
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| subjects | 631/250 631/250/2152 631/250/254 631/250/347 Adult Antibodies, Viral - analysis Chemiluminescence Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - pathology COVID-19 - physiopathology Enzyme-linked immunosorbent assay Fatigue Health care Health Personnel Health problems Humanities and Social Sciences Humans Immune response Immune response (humoral) Immune status Immunity (Disease) Immunity, Mucosal Immunoglobulin A Immunoglobulin A - analysis Immunoglobulin G Immunoglobulin G - analysis Immunoglobulins Long-term effects Medical personnel Middle Aged Mucosal immunity multidisciplinary Respiratory System - immunology Respiratory tract Russia Saliva SARS-CoV-2 - physiology Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Sputum Statistical analysis Young Adult |
| title | Mucosal immunity in health care workers’ respiratory tracts in the post-COVID-19 period |
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