Antimicrobial activity, induction of ROS generation in HepG2 liver cancer cells, and chemical composition of Pterospermum heterophyllum

The objective of this investigation was to assess the inhibitory effects of extracts derived from on bacteria and fungi, as well as their capacity to impede the proliferation and migration of HepG2 liver cancer cells. Extracts from the leaves and stems of revealed the ability to resist all three bac...

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Bibliographic Details
Published in:Open Chemistry 2024-12, Vol.22 (1), p.355-7
Main Authors: Tu, Quang Trung, Le, Thi Thanh Huong, Nguyen, Mai Quynh, Hoang, Phu Hiep, Hoang, Van Hung, Pham, Van Khang, Nguyen, Phu Hung
Format: Article
Language:English
Subjects:
antimicrobial activity
cell migration
cell proliferation
pterospermum heterophyllum
ROS
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Summary:The objective of this investigation was to assess the inhibitory effects of extracts derived from on bacteria and fungi, as well as their capacity to impede the proliferation and migration of HepG2 liver cancer cells. Extracts from the leaves and stems of revealed the ability to resist all three bacterial strains, including , , and ( < 0.05). Additionally, also inhibited the growth of three fungal strains: , , and . Evaluation of anticancer activity showed that extracts from significantly reduced the proliferation of HepG2 cells, with IC values for leaf and stem extracts being 35.5 and 47.17 µg/mL, respectively. Remarkably, the extract of this herbal species inhibited the migration ability of HepG2 cells after 24 h of treatment. Fluorescence analysis of cells using 2-HDCFDA showed a considerable elevation in reactive oxygen species production within HepG2 cells treated with extracts, which is hypothesized to contribute to a reduction in cell viability. Subsequent chemical compound analysis utilizing GC-FID spectra identified some main compounds present in the extracts from . This study highlights the potential antimicrobial and anticancer activities of
ISSN:2391-5420
2391-5420
DOI:10.1515/chem-2024-0125