Genetic Pathways to Insomnia

This review summarizes current research on the genetics of insomnia, as genetic contributions are thought to be important for insomnia etiology. We begin by providing an overview of genetic methods (both quantitative and measured gene), followed by a discussion of the insomnia genetics literature wi...

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Bibliographic Details
Published in:Brain sciences 2016-12, Vol.6 (4), p.64
Main Authors: Lind, Mackenzie J, Gehrman, Philip R
Format: Article
Language:English
Subjects:
Brain
Genetics
genome-wide association study
Insomnia
Review
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Summary:This review summarizes current research on the genetics of insomnia, as genetic contributions are thought to be important for insomnia etiology. We begin by providing an overview of genetic methods (both quantitative and measured gene), followed by a discussion of the insomnia genetics literature with regard to each of the following common methodologies: twin and family studies, candidate gene studies, and genome-wide association studies (GWAS). Next, we summarize the most recent gene identification efforts (primarily GWAS results) and propose several potential mechanisms through which identified genes may contribute to the disorder. Finally, we discuss new genetic approaches and how these may prove useful for insomnia, proposing an agenda for future insomnia genetics research.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci6040064