Differences of Microglia in the Brain and the Spinal Cord

Microglia were previously regarded as a homogenous myeloid cell lineage in the mammalian central nervous system (CNS). However, accumulative evidences show that microglia in the brain and SC are quite different in development, cellular phenotypes and biological functions. How microglia differ betwee...

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Bibliographic Details
Published in:Frontiers in cellular neuroscience 2019-11, Vol.13, p.504-504
Main Authors: Xuan, Fang-Ling, Chithanathan, Keerthana, Lilleväli, Kersti, Yuan, Xiaodong, Tian, Li
Format: Article
Language:English
Subjects:
brain
Cell lineage
Central nervous system
Gene expression
Ligands
Microglia
neuroinflammation
Neurological diseases
Neuroscience
Neurosciences
Phenotypes
Spinal cord
Studies
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Summary:Microglia were previously regarded as a homogenous myeloid cell lineage in the mammalian central nervous system (CNS). However, accumulative evidences show that microglia in the brain and SC are quite different in development, cellular phenotypes and biological functions. How microglia differ between these two regions and whether such diversity may contribute to CNS development and functions as well as neurological diseases will be discussed here.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2019.00504