The effect of different intensities of treadmill exercise on cognitive function deficit following a severe controlled cortical impact in rats

Exercise has been proposed for the treatment of traumatic brain injury (TBI). However, the proper intensity of exercise in the early phase following a severe TBI is largely unknown. To compare two different treadmill exercise intensities on the cognitive function following a severe TBI in its early...

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Bibliographic Details
Published in:International journal of molecular sciences 2013-10, Vol.14 (11), p.21598-21612
Main Authors: Shen, Xiafeng, Li, Aiping, Zhang, Yuling, Dong, Xiaomin, Shan, Tian, Wu, Yi, Jia, Jie, Hu, Yongshan
Format: Article
Language:English
Subjects:
Animal cognition
Animals
BDNF
Brain Injuries - pathology
Brain Injuries - therapy
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Cognition Disorders - metabolism
Cognition Disorders - physiopathology
Cognition Disorders - therapy
Cognitive ability
controlled cortical impact
Exercise
Fitness equipment
Humans
intensity
Maze Learning
Memory
Memory - physiology
Physical Conditioning, Animal
Proteins
Rats
Rehabilitation
spatial memory
Traumatic brain injury
treadmill running
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Summary:Exercise has been proposed for the treatment of traumatic brain injury (TBI). However, the proper intensity of exercise in the early phase following a severe TBI is largely unknown. To compare two different treadmill exercise intensities on the cognitive function following a severe TBI in its early phase, rats experienced a controlled cortical impact (CCI) and were forced to treadmill exercise for 14 days. The results revealed that the rats in the low intensity exercise group had a shorter latency to locate a platform and a significantly better improvement in spatial memory in the Morris water maze (MWM) compared to the control group (p < 0.05). The high intensity exercise group showed a longer latency and a mild improvement in spatial memory compared to the control group rats in the MWM; however, this difference was not statistically significant (p > 0.05). The brain-derived neurotrophic factor (BDNF) and p-CREB protein levels in the contralateral hippocampus were increased significantly in the low intensity exercise group. Our results suggest that 2 weeks of low intensity of treadmill exercise is beneficial for improving cognitive function and increasing hippocampal BDNF expression after a severe TBI in its early phase.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms141121598