Analysis of Gut Microbiota in Patients with Exacerbated Symptoms of Schizophrenia following Therapy with Amisulpride: A Pilot Study

Evidence is mounting that the gut microbiome is related to the underlying pathogenesis of schizophrenia. However, effects of amisulpride on gut microbiota are poorly defined. This study was aimed at analyzing cytokines and fecal microbiota in patients with exacerbated symptoms of schizophrenia treat...

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Bibliographic Details
Published in:Behavioural neurology 2022-03, Vol.2022, p.4262094-10
Main Authors: Zheng, Jinchi, Lin, Zeya, Ko, Chih-Yuan, Xu, Jian-Hua, Lin, Yichuan, Wang, Jinyi
Format: Article
Language:English
Subjects:
Amisulpride - pharmacology
Antipsychotic drugs
Antipsychotics
B cells
Bacteria
Blood pressure
Cholesterol
Cytokines
Fatty acids
Feces
Gastrointestinal Microbiome
Gene amplification
Heart rate
Humans
Interleukins
Mediation
Medical research
Medicine, Experimental
Metabolism
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Pathogenesis
Pilot Projects
Psychopathology
RNA
RNA, Ribosomal, 16S - genetics
Schizophrenia
Schizophrenia - drug therapy
Software
Taxonomy
Tumor necrosis factor-TNF
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Summary:Evidence is mounting that the gut microbiome is related to the underlying pathogenesis of schizophrenia. However, effects of amisulpride on gut microbiota are poorly defined. This study was aimed at analyzing cytokines and fecal microbiota in patients with exacerbated symptoms of schizophrenia treated with amisulpride during four weeks of their hospital stay. In the present study, feces collected from patients with schizophrenia were analyzed using 16S rRNA pyrosequencing and bioinformatic analyses to ascertain gut microbiome composition and fasting peripheral blood cytokines. We found that patients undergoing treatment of schizophrenia with amisulpride had distinct changes in gut microbial composition at the genus level, increased levels of short-chain fatty acid-producing bacteria (Dorea and Butyricicoccus), and reduced levels of pathogenic bacteria (Actinomyces and Porphyromonas), but the level of Desulfovibrio was still high. We also found a significant downregulation of butanoate metabolism based on functional analysis of the microbiome. After treatment, elevated levels of interleukin- (IL-) 4 and decreased levels of IL-6 were found. Our findings extend prior work and suggest a possible pharmacological mechanism of amisulpride treatment for schizophrenia, which acts via mediation of the gut microbiome.
ISSN:0953-4180
1875-8584
DOI:10.1155/2022/4262094