Necroptosis: Molecular Signalling and Translational Implications

Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance. We also...

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Bibliographic Details
Published in:International Journal of Cell Biology 2014, Vol.2014 (2014), p.117-122
Main Authors: Giampietri, Claudia, Starace, Donatella, Petrungaro, Simonetta, Filippini, Antonio, Ziparo, Elio
Format: Article
Language:English
Subjects:
Adapter proteins
Apoptosis
Cancer
Cancer therapies
Cellular signal transduction
Enzymes
Genetic aspects
Genetic translation
Homeostasis
Identification and classification
Kinases
Lymphocytes
Pathogenesis
Phosphorylation
Review
Rodents
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Summary:Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance. We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis.
ISSN:1687-8876
1687-8884
DOI:10.1155/2014/490275