A Rare Case of Mandibular Aspergillus Osteomyelitis in an Immunocompetent Patient

Aspergillosis is a fungal infection caused by Aspergillus species, which is contracted through spores that colonize the respiratory tract, causing rhinosinusitis and pulmonary infections. Oral aspergillosis is rare and, when present, may cause soft tissue and bone destruction, generally in immunodef...

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Published in:Dentistry journal 2022-11, Vol.10 (11), p.213
Main Authors: Faustino, Isabel, Ramos, Joab, Mariz, Bruno, Papadopoulou, Erofili, Georgaki, Maria, Nikitakis, Nikolaos, Vargas, Pablo, Santos-Silva, Alan, Lopes, Marcio
Format: Article
Language:English
Subjects:
Antibiotics
Antifungal agents
Aspergillosis
Aspergillus
Bacterial infections
Case Report
Case reports
Debridement
Dental implants
Dental prosthetics
Disease
Enzymes
Fistula
Fungal infections
Fungi
Immunocompetence
Immunodeficiency
Infections
Itraconazole
Laboratories
Mandible
Microorganisms
mycoses
Osteomyelitis
Patients
Respiratory tract
Rhinosinusitis
Sinuses
Sinusitis
Soft tissues
Spores
Transplants & implants
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creator Faustino, Isabel
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Vargas, Pablo
Santos-Silva, Alan
Lopes, Marcio
description Aspergillosis is a fungal infection caused by Aspergillus species, which is contracted through spores that colonize the respiratory tract, causing rhinosinusitis and pulmonary infections. Oral aspergillosis is rare and, when present, may cause soft tissue and bone destruction, generally in immunodeficient patients. Mandibular Aspergillus osteomyelitis is even rarer, with few cases reported in the literature. A 57-year-old Caucasian woman was referred for the evaluation of painful recurrent swelling in the anterior mandibular alveolar ridge, with purulent drainage, previously treated with multiple surgical debridement procedures and antibiotics without success. The patient was otherwise systemically healthy. Surgical debridement was performed and histopathological examination showed osteomyelitis associated with Aspergillus species. Therapy with oral itraconazole (400 mg per day) was administered for 3 months, resulting in complete resolution. No recurrence was detected after 15 years of follow-up. The patient was rehabilitated with dental implants. In conclusion, non-bacterial microorganisms, such as Aspergillus, should be considered in cases of mandibular osteomyelitis that do not heal after surgical debridement and antibiotic therapy.
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source Publicly Available Content (ProQuest); PubMed Central; Coronavirus Research Database
subjects Antibiotics
Antifungal agents
Aspergillosis
Aspergillus
Bacterial infections
Case Report
Case reports
Debridement
Dental implants
Dental prosthetics
Disease
Enzymes
Fistula
Fungal infections
Fungi
Immunocompetence
Immunodeficiency
Infections
Itraconazole
Laboratories
Mandible
Microorganisms
mycoses
Osteomyelitis
Patients
Respiratory tract
Rhinosinusitis
Sinuses
Sinusitis
Soft tissues
Spores
Transplants & implants
title A Rare Case of Mandibular Aspergillus Osteomyelitis in an Immunocompetent Patient
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