Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies

Hydrogen peroxide (H2O2) is a compound involved in some mammalian reactions and processes. It modulates and signals the redox metabolism of cells by acting as a messenger together with hydrogen sulfide (H2S) and the nitric oxide radical (•NO), activating specific oxidations that determine the metabo...

Full description

Saved in:
Bibliographic Details
Published in:Stresses 2022-09, Vol.2 (3), p.256-274
Main Authors: Andrés, Celia María Curieses, Pérez de la Lastra, José Manuel, Juan, Celia Andrés, Plou, Francisco J., Pérez-Lebeña, Eduardo
Format: Article
Language:English
Subjects:
Biological clocks
Cytochrome
Dehydrogenases
Enzymes
Hydrogen peroxide
hydrogen peroxide H2O2
induced pathologies
Mammals
metabolic response
Metabolism
Oxidation
Oxidative stress
Respiration
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hydrogen peroxide (H2O2) is a compound involved in some mammalian reactions and processes. It modulates and signals the redox metabolism of cells by acting as a messenger together with hydrogen sulfide (H2S) and the nitric oxide radical (•NO), activating specific oxidations that determine the metabolic response. The reaction triggered determines cell survival or apoptosis, depending on which downstream metabolic pathways are activated. There are several ways to produce H2O2 in cells, and cellular systems tightly control its concentration. At the cellular level, the accumulation of hydrogen peroxide can trigger inflammation and even apoptosis, and when its concentration in the blood reaches toxic levels, it can lead to bioenergetic failure. This review summarizes existing research from a chemical perspective on the role of H2O2 in various enzymatic pathways and how this biochemistry leads to physiological or pathological responses.
ISSN:2673-7140
2673-7140
DOI:10.3390/stresses2030019