Targeting thyroid cancer with acid-triggered release of doxorubicin from silicon dioxide nanoparticles

Currently, therapy for thyroid cancer mainly involves surgery and radioiodine therapy. However, chemotherapy can be used in advanced and aggressive thyroid cancer that cannot be treated by other options. Nevertheless, a major obstacle to the successful treatment of thyroid cancer is the delivery of...

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Bibliographic Details
Published in:International journal of nanomedicine 2017-01, Vol.12, p.5993-6003
Main Authors: Li, Shijie, Zhang, Daqi, Sheng, Shihou, Sun, Hui
Format: Article
Language:English
Subjects:
acid-triggered release
Animals
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - pharmacokinetics
Apoptosis
Biomedical materials
Cancer therapies
Cancer treatment
Cell Line, Tumor
Chemotherapy
Dosage and administration
Doxorubicin
Doxorubicin - administration & dosage
Doxorubicin - chemistry
Doxorubicin - pharmacokinetics
Drug delivery systems
Drug Delivery Systems - methods
Drug Liberation
Drug targeting
Drug therapy
Health aspects
Hemodialysis
Humans
Iodine Radioisotopes
Mice, Inbred NOD
Nanocomposites
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Original Research
Scientific imaging
Silicon dioxide
Silicon Dioxide - chemistry
silicon dioxide nanoparticle
Surgery
Technology application
Thyroid cancer
Thyroid Neoplasms - drug therapy
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
Thyrotropin - chemistry
Thyrotropin - metabolism
Tumors
Xenograft Model Antitumor Assays - methods
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Description
Summary:Currently, therapy for thyroid cancer mainly involves surgery and radioiodine therapy. However, chemotherapy can be used in advanced and aggressive thyroid cancer that cannot be treated by other options. Nevertheless, a major obstacle to the successful treatment of thyroid cancer is the delivery of drugs to the thyroid gland. Here, we present an example of the construction of silicon dioxide nanoparticles with thyroid-stimulating-hormone receptor-targeting ligand that can specifically target the thyroid cancer. Doxorubicin nanoparticles can be triggered by acid to release the drug payload for cancer therapy. These nanoparticles shrink the tumor size in vivo with less toxic side effects. This research paves the way toward effective chemotherapy for thyroid cancer.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S137335