Antimicrobial activity of diterpenes from Viguiera arenaria against endodontic bacteria

Six pimarane-type diterpenes isolated from Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated in vitro against a panel of representative microorganisms responsible for dental root canal infections. The microdilution method was used for the determination of the minimum inhibito...

Full description

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2011-01, Vol.16 (1), p.543-551
Main Authors: Carvalho, Tatiane C, Simão, Marília R, Ambrósio, Sérgio R, Furtado, Niege A J C, Veneziani, Rodrigo C S, Heleno, Vladimir C G, Da Costa, Fernando B, Gomes, Brenda P F A, Souza, Maria Gorete M, Borges dos Reis, Erika, Martins, Carlos H G
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
antimicrobial activity
Antimicrobial agents
Bacteria
Bacteria - drug effects
Bacterial infections
Chemicals
Diterpenes - chemistry
Diterpenes - pharmacology
endodontic bacteria
Endodontics
Infections
Magnetic Resonance Spectroscopy
Metabolites
Microbial Sensitivity Tests
Microorganisms
Mouth - microbiology
Pathogens
pimarane diterpenes
structural requirements
Viguiera arenaria
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Six pimarane-type diterpenes isolated from Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated in vitro against a panel of representative microorganisms responsible for dental root canal infections. The microdilution method was used for the determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Porphyromonas gingivalis, Prevotella nigrescens, Prevotella intermedia, Prevotella buccae, Fusobacterium nucleatum, Bacteroides fragilis, Actinomyces naeslundii, Actinomyces viscosus, Peptostreptococcus micros, Enterococcus faecalis and Aggregatibacter actinomycetemcomitans. The compounds ent-pimara-8(14),15-dien-19-oic acid, its sodium salt and ent-8(14),15-pimaradien-3β-ol were the most active, displaying MIC values ranging from 1 to 10 μg mL-1. The results also allow us to conclude that minor structural differences among these diterpenes significantly influence their antimicrobial activity, bringing new perspectives to the discovery of new chemicals for use as a complement to instrumental endodontic procedures.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules160100543