Role of Lactiplantibacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58 and Bifidobacterium longum UBBL-64 in the Wound Healing Process of the Excisional Skin

The probiotics UBLP-40, UBLR-58 and UBBL-64 seem to promote wound healing when applied topically. Our aim was to investigate their effect on the mRNA expression of pro-inflammatory, healing and angiogenetic factors during the healing process of a standardized excisional wound model in rats. Rats sub...

Full description

Saved in:
Bibliographic Details
Published in:Nutrients 2023-04, Vol.15 (8), p.1822
Main Authors: Panagiotou, Dimitrios, Filidou, Eirini, Gaitanidou, Maria, Tarapatzi, Gesthimani, Spathakis, Michail, Kandilogiannakis, Leonidas, Stavrou, George, Arvanitidis, Konstantinos, Tsetis, Joulia K, Gionga, Persefoni, Shrewsbury, Anne D, Manolopoulos, Vangelis G, Kapoukranidou, Dora, Lasithiotakis, Konstantinos, Kolios, George, Kotzampassi, Katerina
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Bifidobacterium longum
Biopsy
Experiments
Gene expression
Humidity
Inflammation
Laboratory animals
Lacticaseibacillus rhamnosus
Lactiplantibacillus plantarum
Lactobacilli
Lactobacillus rhamnosus
Microbiota
Performance evaluation
Pharmaceutical industry
Probiotics
Rats
RNA, Messenger
Skin
skin trauma
Software
Statistical analysis
Variance analysis
Wound Healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The probiotics UBLP-40, UBLR-58 and UBBL-64 seem to promote wound healing when applied topically. Our aim was to investigate their effect on the mRNA expression of pro-inflammatory, healing and angiogenetic factors during the healing process of a standardized excisional wound model in rats. Rats subjected to six dorsal skin wounds were allocated to Control; ; combined formula of plus ; ; and treatments, applied every two days, along with tissue collection. The pro-inflammatory, wound-healing, and angiogenetic factors of mRNA expression were assessed by qRT-PCR. We found that exerts a strong anti-inflammatory effect in relation to - , given alone or in combination; the combined regime of - , works better, greatly promoting the expression of healing and angiogenic factors than . When separately tested, was found to work better than in promoting the expression of healing factors, while seems stronger than in the expression of angiogenic factors. We, therefore, suggest that an ideal probiotic treatment should definitively contain more than one probiotic strain to speed up all three healing phases.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15081822