Antibacterial and Cytotoxic Phenolic Polyketides from Two Marine-Derived Fungal Strains of Aspergillus unguis

A chemical investigation on the EtOAc extracts from two marine-derived fungal strains of resulted in the isolation of three previously undescribed phenolic polyketides including unguidepside C ( ), aspersidone B ( ), and agonodepside C ( ), and their 14 known congeners. The structures of the new com...

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Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2022-01, Vol.15 (1), p.74
Main Authors: Anh, Cao Van, Kwon, Joo-Hee, Kang, Jong Soon, Lee, Hwa-Sun, Heo, Chang-Su, Shin, Hee Jae
Format: Article
Language:English
Subjects:
antibacterial
Antimicrobial agents
Aspergillus unguis
Bacteria
Chlorine
Cytotoxicity
Glycerol
Gram-positive bacteria
marine-derived fungus
Molecular weight
phenolic polyketides
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Summary:A chemical investigation on the EtOAc extracts from two marine-derived fungal strains of resulted in the isolation of three previously undescribed phenolic polyketides including unguidepside C ( ), aspersidone B ( ), and agonodepside C ( ), and their 14 known congeners. The structures of the new compounds were determined based on detailed analysis and comparison of their spectroscopic data with literature values, as well as Snatzke's method. The new compounds ( , , and ) displayed a significant anti-Gram-positive bacterial activity, with MIC values ranging from 5.3 to 22.1 µM. Additionally, the isolated compounds ( - and - ) were evaluated for their cytotoxicity against a panel of tumor cell lines. Most of them (except for ) displayed cytotoxicity against all the tested cell lines, with IC values ranging from 2.5 to 46.9 µM.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph15010074