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Antibacterial and Cytotoxic Phenolic Polyketides from Two Marine-Derived Fungal Strains of Aspergillus unguis
A chemical investigation on the EtOAc extracts from two marine-derived fungal strains of resulted in the isolation of three previously undescribed phenolic polyketides including unguidepside C ( ), aspersidone B ( ), and agonodepside C ( ), and their 14 known congeners. The structures of the new com...
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| Published in: | Pharmaceuticals (Basel, Switzerland) Switzerland), 2022-01, Vol.15 (1), p.74 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c472t-e6e235b651f545241e6b0f3e8c3bd65299d3f1ad1ac985daafc8ca6afe3f59193 |
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| container_start_page | 74 |
| container_title | Pharmaceuticals (Basel, Switzerland) |
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| creator | Anh, Cao Van Kwon, Joo-Hee Kang, Jong Soon Lee, Hwa-Sun Heo, Chang-Su Shin, Hee Jae |
| description | A chemical investigation on the EtOAc extracts from two marine-derived fungal strains of
resulted in the isolation of three previously undescribed phenolic polyketides including unguidepside C (
), aspersidone B (
), and agonodepside C (
), and their 14 known congeners. The structures of the new compounds were determined based on detailed analysis and comparison of their spectroscopic data with literature values, as well as Snatzke's method. The new compounds (
,
, and
) displayed a significant anti-Gram-positive bacterial activity, with MIC values ranging from 5.3 to 22.1 µM. Additionally, the isolated compounds (
-
and
-
) were evaluated for their cytotoxicity against a panel of tumor cell lines. Most of them (except for
) displayed cytotoxicity against all the tested cell lines, with IC
values ranging from 2.5 to 46.9 µM. |
| doi_str_mv | 10.3390/ph15010074 |
| format | article |
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resulted in the isolation of three previously undescribed phenolic polyketides including unguidepside C (
), aspersidone B (
), and agonodepside C (
), and their 14 known congeners. The structures of the new compounds were determined based on detailed analysis and comparison of their spectroscopic data with literature values, as well as Snatzke's method. The new compounds (
,
, and
) displayed a significant anti-Gram-positive bacterial activity, with MIC values ranging from 5.3 to 22.1 µM. Additionally, the isolated compounds (
-
and
-
) were evaluated for their cytotoxicity against a panel of tumor cell lines. Most of them (except for
) displayed cytotoxicity against all the tested cell lines, with IC
values ranging from 2.5 to 46.9 µM.</description><identifier>ISSN: 1424-8247</identifier><identifier>EISSN: 1424-8247</identifier><identifier>DOI: 10.3390/ph15010074</identifier><identifier>PMID: 35056132</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>antibacterial ; Antimicrobial agents ; Aspergillus unguis ; Bacteria ; Chlorine ; Cytotoxicity ; Glycerol ; Gram-positive bacteria ; marine-derived fungus ; Molecular weight ; phenolic polyketides</subject><ispartof>Pharmaceuticals (Basel, Switzerland), 2022-01, Vol.15 (1), p.74</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-e6e235b651f545241e6b0f3e8c3bd65299d3f1ad1ac985daafc8ca6afe3f59193</citedby><cites>FETCH-LOGICAL-c472t-e6e235b651f545241e6b0f3e8c3bd65299d3f1ad1ac985daafc8ca6afe3f59193</cites><orcidid>0000-0002-5952-5325 ; 0000-0003-0435-5688 ; 0000-0001-7984-641X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2621348739/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2621348739?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35056132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anh, Cao Van</creatorcontrib><creatorcontrib>Kwon, Joo-Hee</creatorcontrib><creatorcontrib>Kang, Jong Soon</creatorcontrib><creatorcontrib>Lee, Hwa-Sun</creatorcontrib><creatorcontrib>Heo, Chang-Su</creatorcontrib><creatorcontrib>Shin, Hee Jae</creatorcontrib><title>Antibacterial and Cytotoxic Phenolic Polyketides from Two Marine-Derived Fungal Strains of Aspergillus unguis</title><title>Pharmaceuticals (Basel, Switzerland)</title><addtitle>Pharmaceuticals (Basel)</addtitle><description>A chemical investigation on the EtOAc extracts from two marine-derived fungal strains of
resulted in the isolation of three previously undescribed phenolic polyketides including unguidepside C (
), aspersidone B (
), and agonodepside C (
), and their 14 known congeners. The structures of the new compounds were determined based on detailed analysis and comparison of their spectroscopic data with literature values, as well as Snatzke's method. The new compounds (
,
, and
) displayed a significant anti-Gram-positive bacterial activity, with MIC values ranging from 5.3 to 22.1 µM. Additionally, the isolated compounds (
-
and
-
) were evaluated for their cytotoxicity against a panel of tumor cell lines. Most of them (except for
) displayed cytotoxicity against all the tested cell lines, with IC
values ranging from 2.5 to 46.9 µM.</description><subject>antibacterial</subject><subject>Antimicrobial agents</subject><subject>Aspergillus unguis</subject><subject>Bacteria</subject><subject>Chlorine</subject><subject>Cytotoxicity</subject><subject>Glycerol</subject><subject>Gram-positive bacteria</subject><subject>marine-derived fungus</subject><subject>Molecular weight</subject><subject>phenolic polyketides</subject><issn>1424-8247</issn><issn>1424-8247</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkk1v1DAQQCMEoqVw4QcgS1xQpYA_Y_uCtFpaqFQEEuVsOfZ410sSb-2ksP-eLFtKy8kjz_ObGWuq6iXBbxnT-N12TQQmGEv-qDomnPJaUS4f34uPqmelbDAWknDytDpiAouGMHpc9YthjK11I-RoO2QHj5a7MY3pV3To6xqG1O2D1O1-wBg9FBRy6tHVz4Q-2xwHqD_ML2_Ao_NpWM2Gb2O2cSgoBbQoW8ir2HVTQXNyiuV59STYrsCL2_Ok-n5-drX8VF9--XixXFzWjks61tAAZaJtBAmCC8oJNC0ODJRjrW8E1dqzQKwn1mklvLXBKWcbG4AFoYlmJ9XFweuT3Zhtjr3NO5NsNH8uUl4Zm8foOjBEYgGau7mU4th7TWRQLSeCYIEbkLPr_cG1ndoevINhnrB7IH2YGeLarNKNUVJqpcgseHMryOl6gjKaPhYHXWcHSFMxtKGUKsG1mNHX_6GbNOVh_qo9RRhXku2nOz1QLqdSMoS7Zgg2-40w_zZihl_db_8O_bsC7Dc5h7IZ</recordid><startdate>20220106</startdate><enddate>20220106</enddate><creator>Anh, Cao Van</creator><creator>Kwon, Joo-Hee</creator><creator>Kang, Jong Soon</creator><creator>Lee, Hwa-Sun</creator><creator>Heo, Chang-Su</creator><creator>Shin, Hee Jae</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5952-5325</orcidid><orcidid>https://orcid.org/0000-0003-0435-5688</orcidid><orcidid>https://orcid.org/0000-0001-7984-641X</orcidid></search><sort><creationdate>20220106</creationdate><title>Antibacterial and Cytotoxic Phenolic Polyketides from Two Marine-Derived Fungal Strains of Aspergillus unguis</title><author>Anh, Cao Van ; Kwon, Joo-Hee ; Kang, Jong Soon ; Lee, Hwa-Sun ; Heo, Chang-Su ; Shin, Hee Jae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-e6e235b651f545241e6b0f3e8c3bd65299d3f1ad1ac985daafc8ca6afe3f59193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>antibacterial</topic><topic>Antimicrobial agents</topic><topic>Aspergillus unguis</topic><topic>Bacteria</topic><topic>Chlorine</topic><topic>Cytotoxicity</topic><topic>Glycerol</topic><topic>Gram-positive bacteria</topic><topic>marine-derived fungus</topic><topic>Molecular weight</topic><topic>phenolic polyketides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anh, Cao Van</creatorcontrib><creatorcontrib>Kwon, Joo-Hee</creatorcontrib><creatorcontrib>Kang, Jong Soon</creatorcontrib><creatorcontrib>Lee, Hwa-Sun</creatorcontrib><creatorcontrib>Heo, Chang-Su</creatorcontrib><creatorcontrib>Shin, Hee Jae</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Pharmaceuticals (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anh, Cao Van</au><au>Kwon, Joo-Hee</au><au>Kang, Jong Soon</au><au>Lee, Hwa-Sun</au><au>Heo, Chang-Su</au><au>Shin, Hee Jae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial and Cytotoxic Phenolic Polyketides from Two Marine-Derived Fungal Strains of Aspergillus unguis</atitle><jtitle>Pharmaceuticals (Basel, Switzerland)</jtitle><addtitle>Pharmaceuticals (Basel)</addtitle><date>2022-01-06</date><risdate>2022</risdate><volume>15</volume><issue>1</issue><spage>74</spage><pages>74-</pages><issn>1424-8247</issn><eissn>1424-8247</eissn><abstract>A chemical investigation on the EtOAc extracts from two marine-derived fungal strains of
resulted in the isolation of three previously undescribed phenolic polyketides including unguidepside C (
), aspersidone B (
), and agonodepside C (
), and their 14 known congeners. The structures of the new compounds were determined based on detailed analysis and comparison of their spectroscopic data with literature values, as well as Snatzke's method. The new compounds (
,
, and
) displayed a significant anti-Gram-positive bacterial activity, with MIC values ranging from 5.3 to 22.1 µM. Additionally, the isolated compounds (
-
and
-
) were evaluated for their cytotoxicity against a panel of tumor cell lines. Most of them (except for
) displayed cytotoxicity against all the tested cell lines, with IC
values ranging from 2.5 to 46.9 µM.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35056132</pmid><doi>10.3390/ph15010074</doi><orcidid>https://orcid.org/0000-0002-5952-5325</orcidid><orcidid>https://orcid.org/0000-0003-0435-5688</orcidid><orcidid>https://orcid.org/0000-0001-7984-641X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1424-8247 |
| ispartof | Pharmaceuticals (Basel, Switzerland), 2022-01, Vol.15 (1), p.74 |
| issn | 1424-8247 1424-8247 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_1705e94c1f5840dd917f8b41510506e7 |
| source | Publicly Available Content Database; PubMed |
| subjects | antibacterial Antimicrobial agents Aspergillus unguis Bacteria Chlorine Cytotoxicity Glycerol Gram-positive bacteria marine-derived fungus Molecular weight phenolic polyketides |
| title | Antibacterial and Cytotoxic Phenolic Polyketides from Two Marine-Derived Fungal Strains of Aspergillus unguis |
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