Necroptosis could serve as an indicator of therapeutic resistance in viral induced well-differentiated oral squamous cell carcinoma?

• Published in: Oral oncology reports 2024-06, Vol.10, p.100378, Article 100378
• Main Authors: Krishnasamy, Nitya, Ramadoss, Ramya, Panneer Selvam, Suganya, Sundar, Sandhya, Hemashree, K.
• Format: Article
• Language: English
• Subjects: Necroptosis; Oral squamous cell carcinoma; Virus induced oral cancers
• ISSN: 2772-9060; 2772-9060
• DOI: 10.1016/j.oor.2024.100378

Exploring necroptosis as an indicator of therapeutic resistance in viral-induced well-differentiated oral squamous cell carcinoma (OSCC) is to elucidate its potential role in predicting treatment outcomes and guiding therapeutic decisions. By understanding the relationship between necroptosis levels and therapeutic resistance, oncologists can aim to identify novel biomarkers and therapeutic targets that could improve patient management and outcomes in viral-induced OSCC. Viral-induced oral squamous cell carcinoma (OSCC) presents with disrupted cellular functions, dysregulation of apoptotic pathways, evasion of programmed cell death and resistance to conventional anticancer treatments. Concurrently, alterations in pro-inflammatory cytokines and chemokines drive tumorigenesis in viral-induced squamous cell carcinoma, impairing anti-viral immune responses. Monitoring necroptosis levels in viral-induced OSCC offers insights into therapy resistance, as high levels may indicate reduced responsiveness to standard treatments. Understanding the role of necroptosis in therapy resistance could pave the way for the development of targeted therapies that exploit necroptosis pathways to overcome resistance and improve treatment outcomes in viral-induced OSCC. •Tumour necrosis/necroptosis (TNN) is a frequently found histopathological feature in solid tumours including OSCC.•Viral-induced oral squamous cell carcinoma (OSCC) presents with disrupted cellular functions, dysregulation of apoptotic pathways, evasion of programmed cell death and resistance to conventional anticancer treatments.•Presence of necroptosis in well-differentiated OSCC could denote that the lesion is progressing to an aggressive mode.•Monitoring necroptosis levels in viral-induced OSCC offers insights into therapy resistance, as high levels may indicate reduced responsiveness to standard treatments.•Understanding the role of necroptosis in therapy resistance could pave the way for the development of targeted therapies.