The Ser290Asn and Thr715Pro Polymorphisms of the SELP Gene Are Associated with A Lower Risk of Developing Acute Coronary Syndrome and Low Soluble P-Selectin Levels in A Mexican Population

• Published in: Biomolecules (Basel, Switzerland) Switzerland), 2020-02, Vol.10 (2), p.270
• Main Authors: Herrera-Maya, Gabriel, Vargas-Alarcón, Gilberto, Pérez-Méndez, Oscar, Posadas-Sánchez, Rosalinda, Masso, Felipe, Juárez-Cedillo, Teresa, Escobedo, Galileo, Vázquez-Montero, Andros, Fragoso, José Manuel
• Format: Article
• Language: English
• Subjects: acute coronary syndrome; Acute Coronary Syndrome - epidemiology; Acute Coronary Syndrome - genetics; Aged; Case-Control Studies; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; genetics; Heart Disease Risk Factors; Humans; Linkage Disequilibrium; Male; Mexico - epidemiology; Middle Aged; Odds Ratio; p-selectin; P-Selectin - blood; P-Selectin - genetics; Polymorphism, Single Nucleotide - physiology; polymorphisms; susceptibility
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom10020270

Recent studies have shown that P-selectin promotes the early formation of atherosclerotic plaque. The aim of the present study was to evaluate whether the gene single nucleotide polymorphisms (SNPs) are associated with presence of acute coronary syndrome (ACS) and with plasma P-selectin levels in a case-control association study. The sample size was estimated for a statistical power of 80%. We genotyped three ( Ser290Asn, Leu599Val, and Thr715Pro) SNPs using 5' exonuclease TaqMan assays in 625 patients with ACS and 700 healthy controls. The associations were evaluated with logistic regressions under the co-dominant, dominant, recessive, over-dominant and additive inheritance models. The genotype contribution to the plasma P-selectin levels was evaluated by a Student's t-test. Under different models, the Ser290Asn (OR = 0.59, = 0.047; OR = 0.59, = 0.014; OR = 0.58, = 0.061, and OR = 0.62, = 0.015) and Thr715Pro (OR = 0.61, = 0.028; OR = 0.63, = 0.044, and OR = 0.62, = 0.023) SNPs were associated with a lower risk of ACS. In addition, these SNPs were associated with low plasma P-selectin levels. In summary, this study established that the Ser290Asn and Thr715Pro SNPs are associated with a lower risk of developing ACS and with decreased P-selectin levels in plasma in a Mexican population.