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Acute morphological and physiological effects of lead in the neotropical fish Prochilodus lineatus
The present study investigated lead effects on gill morphology, hematocrit, blood sodium, glucose, lipids, protein, and cholesterol of Prochilodus lineatus exposed to two sublethal lead concentrations for 96 h. Preliminary series of short-term static toxicity tests were run to determine LC50 (96 h)...
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Published in: | Brazilian journal of biology 2004-11, Vol.64 (4), p.797-807 |
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description | The present study investigated lead effects on gill morphology, hematocrit, blood sodium, glucose, lipids, protein, and cholesterol of Prochilodus lineatus exposed to two sublethal lead concentrations for 96 h. Preliminary series of short-term static toxicity tests were run to determine LC50 (96 h) of lead in P. lineatus, which was 95 mg Pb.L-1. Therefore, lead concentrations tested in the sublethal experiments were 24 and 71 mg Pb.L-1, which correspond to 25% and 75% of the LC50 (96 h), respectively. Gills of P. lineatus exposed to both lead concentrations during 96 h presented a higher occurrence of histopathological lesions such as epithelial lifting, hyperplasia, and lamellar aneurism. P. lineatus did not show significant alterations in hematocrit during exposure to both lead concentrations. Fish exposed to the highest lead concentration showed a significant decrease in Na+ plasma concentration after 48 h, possibly reflecting a sodium influx rate decrease. P. lineatus exposed to both lead concentrations presented a "classical general adaptation syndrome to stress", as hyperglycemia associated with lowered lipids and proteins was reported. Stress-response magnitude was dose-dependent. While the response to the lowest lead concentration might represent adaptation, the highest concentration seems to characterize exhaustion. |
doi_str_mv | 10.1590/s1519-69842004000500009 |
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Preliminary series of short-term static toxicity tests were run to determine LC50 (96 h) of lead in P. lineatus, which was 95 mg Pb.L-1. Therefore, lead concentrations tested in the sublethal experiments were 24 and 71 mg Pb.L-1, which correspond to 25% and 75% of the LC50 (96 h), respectively. Gills of P. lineatus exposed to both lead concentrations during 96 h presented a higher occurrence of histopathological lesions such as epithelial lifting, hyperplasia, and lamellar aneurism. P. lineatus did not show significant alterations in hematocrit during exposure to both lead concentrations. Fish exposed to the highest lead concentration showed a significant decrease in Na+ plasma concentration after 48 h, possibly reflecting a sodium influx rate decrease. P. lineatus exposed to both lead concentrations presented a "classical general adaptation syndrome to stress", as hyperglycemia associated with lowered lipids and proteins was reported. Stress-response magnitude was dose-dependent. 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Preliminary series of short-term static toxicity tests were run to determine LC50 (96 h) of lead in P. lineatus, which was 95 mg Pb.L-1. Therefore, lead concentrations tested in the sublethal experiments were 24 and 71 mg Pb.L-1, which correspond to 25% and 75% of the LC50 (96 h), respectively. Gills of P. lineatus exposed to both lead concentrations during 96 h presented a higher occurrence of histopathological lesions such as epithelial lifting, hyperplasia, and lamellar aneurism. P. lineatus did not show significant alterations in hematocrit during exposure to both lead concentrations. Fish exposed to the highest lead concentration showed a significant decrease in Na+ plasma concentration after 48 h, possibly reflecting a sodium influx rate decrease. P. lineatus exposed to both lead concentrations presented a "classical general adaptation syndrome to stress", as hyperglycemia associated with lowered lipids and proteins was reported. Stress-response magnitude was dose-dependent. While the response to the lowest lead concentration might represent adaptation, the highest concentration seems to characterize exhaustion.</description><subject>Adaptation, Physiological</subject><subject>Animals</subject><subject>BIOLOGY</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fishes - blood</subject><subject>Fishes - physiology</subject><subject>gill histopathology</subject><subject>Gills - drug effects</subject><subject>Gills - pathology</subject><subject>lead</subject><subject>Lead - toxicity</subject><subject>Lethal Dose 50</subject><subject>plasma sodium</subject><subject>Prochilodus lineatus</subject><subject>stress response</subject><subject>Time Factors</subject><subject>Toxicity Tests, Acute - methods</subject><issn>1519-6984</issn><issn>1678-4375</issn><issn>1519-6984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9UctOJCEUJcaJr5lfmGHlrhWqgKKWxsyMJiaajHvC42LRoYsSqhb-vWh3WpNJXBDI5bxyLkK_KLmgvCeXhXLar0QvWUMII4Twekh_gE72H4ef3sfotJQ1IQ0nrTxCx5R3jFXqCTJXdpkBb1KehhTTU7A6Yj06PA0vJewn4D3YueDkcQTtcBjxPAAeIc05Te8QH8qAH3KyQ4jJLQXHMIKel_IdffM6Fvixu8_Q45_fj9c3q7v7v7fXV3crywSvOaVuPXgAZ3qwzDInhXRSetEbYYzkomVeOs4bbYhutAXfdV5Y6B3XlLdn6HYr65JeqymHjc4vKumg3gcpPymd52AjKNpR0lBJGNCOGUc1pdZyJoz1wG0PVetiq1VsgJjUOi15rNnVv7dK1X-9V8L5ljDl9LxAmdUmFAsx6lrRUqqjbKmQrAK7LdDmVEoGv09KiXpb7RcWP3cWi9mA--Dtdtm-ArjBnmA</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>Martinez, C B R</creator><creator>Nagae, M Y</creator><creator>Zaia, C T B V</creator><creator>Zaia, D A M</creator><general>Instituto Internacional de Ecologia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>GPN</scope><scope>DOA</scope></search><sort><creationdate>20041101</creationdate><title>Acute morphological and physiological effects of lead in the neotropical fish Prochilodus lineatus</title><author>Martinez, C B R ; Nagae, M Y ; Zaia, C T B V ; Zaia, D A M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4659-68a3fefeedb9ec4c4d868d88f69b6bb85634f8d552ab0a2acef77f6ce9d5a153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adaptation, Physiological</topic><topic>Animals</topic><topic>BIOLOGY</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fishes - blood</topic><topic>Fishes - physiology</topic><topic>gill histopathology</topic><topic>Gills - drug effects</topic><topic>Gills - pathology</topic><topic>lead</topic><topic>Lead - toxicity</topic><topic>Lethal Dose 50</topic><topic>plasma sodium</topic><topic>Prochilodus lineatus</topic><topic>stress response</topic><topic>Time Factors</topic><topic>Toxicity Tests, Acute - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martinez, C B R</creatorcontrib><creatorcontrib>Nagae, M Y</creatorcontrib><creatorcontrib>Zaia, C T B V</creatorcontrib><creatorcontrib>Zaia, D A M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>SciELO</collection><collection>Directory of Open Access Journals</collection><jtitle>Brazilian journal of biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martinez, C B R</au><au>Nagae, M Y</au><au>Zaia, C T B V</au><au>Zaia, D A M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute morphological and physiological effects of lead in the neotropical fish Prochilodus lineatus</atitle><jtitle>Brazilian journal of biology</jtitle><addtitle>Braz J Biol</addtitle><date>2004-11-01</date><risdate>2004</risdate><volume>64</volume><issue>4</issue><spage>797</spage><epage>807</epage><pages>797-807</pages><issn>1519-6984</issn><issn>1678-4375</issn><eissn>1519-6984</eissn><abstract>The present study investigated lead effects on gill morphology, hematocrit, blood sodium, glucose, lipids, protein, and cholesterol of Prochilodus lineatus exposed to two sublethal lead concentrations for 96 h. Preliminary series of short-term static toxicity tests were run to determine LC50 (96 h) of lead in P. lineatus, which was 95 mg Pb.L-1. Therefore, lead concentrations tested in the sublethal experiments were 24 and 71 mg Pb.L-1, which correspond to 25% and 75% of the LC50 (96 h), respectively. Gills of P. lineatus exposed to both lead concentrations during 96 h presented a higher occurrence of histopathological lesions such as epithelial lifting, hyperplasia, and lamellar aneurism. P. lineatus did not show significant alterations in hematocrit during exposure to both lead concentrations. Fish exposed to the highest lead concentration showed a significant decrease in Na+ plasma concentration after 48 h, possibly reflecting a sodium influx rate decrease. P. lineatus exposed to both lead concentrations presented a "classical general adaptation syndrome to stress", as hyperglycemia associated with lowered lipids and proteins was reported. Stress-response magnitude was dose-dependent. 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subjects | Adaptation, Physiological Animals BIOLOGY Dose-Response Relationship, Drug Fishes - blood Fishes - physiology gill histopathology Gills - drug effects Gills - pathology lead Lead - toxicity Lethal Dose 50 plasma sodium Prochilodus lineatus stress response Time Factors Toxicity Tests, Acute - methods |
title | Acute morphological and physiological effects of lead in the neotropical fish Prochilodus lineatus |
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