Prognostic significance of the infiltration of CD163+ macrophages combined with CD66b+ neutrophils in gastric cancer

The polarization of tumor‐associated macrophages (TAMs) and tumor‐associated neutrophils (TANs), especially from the antitumoral phenotype to the protumoral phenotype under certain conditions, has an important influence on the progression of tumors. However, the interactions and combined prognosis o...

Full description

Saved in:
Bibliographic Details
Published in:Cancer medicine (Malden, MA) MA), 2018-05, Vol.7 (5), p.1731-1741
Main Authors: Huang, Xiaopei, Pan, Yamin, Ma, Jun, Kang, Zhengchun, Xu, Xiaowen, Zhu, Yan, Chen, Jikuai, Zhang, Wei, Chang, Wenjun, Zhu, Jiangbo
Format: Article
Language:English
Subjects:
Antigens, CD - metabolism
Antigens, Differentiation, Myelomonocytic - metabolism
Cell Adhesion Molecules - metabolism
Chemotherapy
Clinical Cancer Research
Female
Gastric cancer
GPI-Linked Proteins - metabolism
Humans
immune microenvironment
macrophages
Macrophages - immunology
Male
Medical prognosis
Neoplasm Recurrence, Local
Neutrophil Infiltration
Neutrophils
Neutrophils - immunology
Original Research
Prognosis
Receptors, Cell Surface - metabolism
Stomach Neoplasms - immunology
Survival Analysis
Tissue Array Analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The polarization of tumor‐associated macrophages (TAMs) and tumor‐associated neutrophils (TANs), especially from the antitumoral phenotype to the protumoral phenotype under certain conditions, has an important influence on the progression of tumors. However, the interactions and combined prognosis of these cells are poorly known. Here, we detected the infiltration of CD68+ TAMs, CD163+ TAMs, and CD66b+ TANs in the specimens from 662 patients with GC by immunohistochemistry. The results showed that the infiltration of each of CD163+, CD68+, and CD66b+ cells in GC tissue was significantly increased and independently associated with GC prognosis. Strong collinearity (r = 0.690, P 
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.1420