Effect of Aqueous Extract of F. capensis Leaves and Its Combination with C. aconitifolius Leaves on Essential Biochemical Parameters of Phenylhydrazine-Induced Anemic Rats

Moraceae and Euphorbiaceae leaves have been used separately in traditional medical practice to treat different ailments, of which anemia is one. This study aims to evaluate the effect of and on hepatic, renal parameters and oxidative stress of phenylhydrazine-induced anemic rats. Thirty-five rats we...

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Bibliographic Details
Published in:Journal of experimental pharmacology 2020, Vol.12, p.191-201
Main Authors: Ezeigwe, Obiajulu Christian, Nzekwe, Favour Amarachi, Nworji, Ogechukwu Frances, Ezennaya, Chidinma Felicia, Iloanya, Ebele Lauretta, Asogwa, Kingsley Kelechi
Format: Article
Language:English
Subjects:
Anemia
Animals
Antioxidants
aspartate transaminase
Bilirubin
cnidoscolus aconitifolius
creatinine
Electrolytes
Enzymes
ficus capensis
Hematology
Herbal medicine
Hydrazine (Compound)
Laboratories
Lipoproteins
Liver
Local government
Low density lipoproteins
Original Research
phenylhydrazine
Phosphatases
Plant sciences
Potassium
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Summary:Moraceae and Euphorbiaceae leaves have been used separately in traditional medical practice to treat different ailments, of which anemia is one. This study aims to evaluate the effect of and on hepatic, renal parameters and oxidative stress of phenylhydrazine-induced anemic rats. Thirty-five rats were randomized into seven groups (A-G) of five rats each. Groups A and B served as the normal control and anemic control, respectively, while Groups C, D, E, F, and G were treated with a standard drug (vitamin B ), 200mg/kg bw. aqueous extract of , 400mg/kg b.w. aqueous extract of , 200mg/kg bw. of a combination of aqueous extract of and and 400mg/kg bw. of a combination of aqueous extract of and respectively. The biochemical analysis (liver and kidney function analysis, oxidative stress) was carried out using standard diagnostic techniques. The results showed that there was significant decrease (
ISSN:1179-1454
1179-1454
DOI:10.2147/JEP.S254003