Avian Stress-Related Transcriptome and Selenotranscriptome: Role during Exposure to Heavy Metals and Heat Stress

Selenium, through incorporation into selenoproteins, is one of the key elements of the antioxidant system. Over the past few years there has been increased interest in exploring those molecular mechanisms in chicken, responsible for the development of this protection system. In more detail, Cd/Pb po...

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Bibliographic Details
Published in:Antioxidants 2019-07, Vol.8 (7), p.216
Main Authors: Seremelis, Isidoros, Danezis, Georgios P, Pappas, Athanasios C, Zoidis, Evangelos, Fegeros, Kostas
Format: Article
Language:English
Subjects:
Animal health
Antioxidants
Apoptosis
Cadmium
chickens
Cytokines
Gene expression
Heat shock proteins
Heat stress
Heavy metals
Inflammation
Kidneys
lead
Lead content
lead poisoning
Lymphocytes
messenger RNA
Molecular modelling
Neutrophils
Nitric oxide
Oxidation
Protein expression
Review
Selenium
selenoprotein
Selenoproteins
selenotranscriptome
Toxicity
transcriptome
Transcriptomes
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Summary:Selenium, through incorporation into selenoproteins, is one of the key elements of the antioxidant system. Over the past few years there has been increased interest in exploring those molecular mechanisms in chicken, responsible for the development of this protection system. In more detail, Cd/Pb poisoning and heat stress increase oxidation, mRNA levels of inflammatory proteins, and apoptotic proteins. Selenium seems to enhance the antioxidant status and alleviates these effects via upregulation of antioxidant proteins and other molecular effects. In this review, we analyze avian transcriptome key elements with particular emphasis on interactions with heavy metals and on relation to heat stress.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox8070216