Compositional constraints in the extremely GC-poor genome of Plasmodium falciparum

We have analyzed the compositional properties of coding (protein encoding) and non-coding sequences of Plasmodium falciparum, a unicellular parasite characterized by an extremely AT-rich genome. GC% levels, base and dinucleotide frequencies were studied. We found that among the various factors that...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 1997-11, Vol.92 (6), p.835-841
Main Authors: Musto, H, Cacciò, S, Rodríguez-Maseda, H, Bernardi, G
Format: Article
Language:English
Subjects:
Animals
Base Composition
Chromosome Mapping
Cytosine
dinucleotides
GC levels
genome organization
Genome, Protozoan
Guanine
PARASITOLOGY
Plasmodium falciparum
Plasmodium falciparum - GC levels - dinucleotides - genome organization
Plasmodium falciparum - genetics
TROPICAL MEDICINE
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Summary:We have analyzed the compositional properties of coding (protein encoding) and non-coding sequences of Plasmodium falciparum, a unicellular parasite characterized by an extremely AT-rich genome. GC% levels, base and dinucleotide frequencies were studied. We found that among the various factors that contribute to the properties of the sequences analyzed, the most relevant are the compositional constraints which operate on the whole genome.
ISSN:1678-8060
0074-0276
0074-0276
1678-8060
DOI:10.1590/S0074-02761997000600020