Toxicity to sea urchin egg development of the quinone fraction obtained from Auxemma oncocalyx

Auxemma oncocalyx Taub. belongs to the Boraginaceae family and is native to the Brazilian northeast where it is known as "pau-branco". We investigated the ability of the water soluble fraction isolated from the heartwood of A. oncocalyx to inhibit sea urchin egg development. This fraction...

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Published in:Brazilian journal of medical and biological research 2002-08, Vol.35 (8), p.927-930
Main Authors: Costa-Lotufo, L V, Ferreira, M A D, Lemos, T L G, Pessoa, O D L, Viana, G S B, Cunha, G M A
Format: Article
Language:English
Subjects:
Animals
Anthraquinones - isolation & purification
Anthraquinones - toxicity
Antineoplastic Agents - toxicity
Auxemma oncocalyx
BIOLOGY
Boraginaceae - chemistry
DNA Damage
MEDICINE, RESEARCH & EXPERIMENTAL
Oncocalyxone A
Ovum - drug effects
Plant Extracts - toxicity
Quinones
Quinones - isolation & purification
Quinones - toxicity
Sea urchin eggs
Sea Urchins
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cited_by cdi_FETCH-LOGICAL-c463t-b320d3072a885ee035326cccf7f7eeebfb187cdd5ee7ed2d1dd2c9ff0cc309673
cites cdi_FETCH-LOGICAL-c463t-b320d3072a885ee035326cccf7f7eeebfb187cdd5ee7ed2d1dd2c9ff0cc309673
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container_issue 8
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container_title Brazilian journal of medical and biological research
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creator Costa-Lotufo, L V
Ferreira, M A D
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Cunha, G M A
description Auxemma oncocalyx Taub. belongs to the Boraginaceae family and is native to the Brazilian northeast where it is known as "pau-branco". We investigated the ability of the water soluble fraction isolated from the heartwood of A. oncocalyx to inhibit sea urchin egg development. This fraction contains about 80% oncocalyxone A (quinone fraction), a compound known to possess strong cytotoxic and antitumor activities. In fact, the quinone fraction inhibited cleavage in a dose-dependent manner [IC50 of 18.4 (12.4-27.2) microg/ml, N = 6], and destroyed the embryos in the blastula stage [IC50 of 16.2 (13.7-19.2) microg/ml, N = 6]. We suggest that this activity is due to the presence of oncocalyxone A. In fact, these quinones present in A. oncocalyx extract have strong toxicity related to their antimitotic activity.
doi_str_mv 10.1590/S0100-879X2002000800010
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identifier ISSN: 0100-879X
ispartof Brazilian journal of medical and biological research, 2002-08, Vol.35 (8), p.927-930
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source IngentaConnect Journals; SciELO
subjects Animals
Anthraquinones - isolation & purification
Anthraquinones - toxicity
Antineoplastic Agents - toxicity
Auxemma oncocalyx
BIOLOGY
Boraginaceae - chemistry
DNA Damage
MEDICINE, RESEARCH & EXPERIMENTAL
Oncocalyxone A
Ovum - drug effects
Plant Extracts - toxicity
Quinones
Quinones - isolation & purification
Quinones - toxicity
Sea urchin eggs
Sea Urchins
title Toxicity to sea urchin egg development of the quinone fraction obtained from Auxemma oncocalyx
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