Intergenerational Impact of Parental Zinc Deficiency on Metabolic and Redox Outcomes in Drosophila melanogaster

Zinc deficiency is a common nutritional disorder with detrimental health consequences. Whether parental zinc deficiency induces intergenerational effects remains largely unknown. We investigated the effects of a combined maternal and paternal zinc deficiency on offspring's metabolic outcomes an...

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Bibliographic Details
Published in:Biology (Basel, Switzerland) Switzerland), 2024-06, Vol.13 (6), p.401
Main Authors: Sanusi, Kamaldeen Olalekan, Ibrahim, Kasimu Ghandi, Abubakar, Murtala Bello, Shinkafi, Tijjani Salihu, Ishaka, Aminu, Imam, Mustapha Umar
Format: Article
Language:English
Subjects:
Antioxidants
Body weight
Drosophila
Drosophila melanogaster
Enzymes
Fruit-flies
Gene expression
Generations
Glucose
Glucose metabolism
Homeostasis
Inflammation
Insects
intergenerational effects
Life sciences
Lipid metabolism
metabolic pathways
Metabolism
Nutrient deficiency
Offspring
parental zinc deficiency
Pregnancy
RNA transport
Zinc
Zinc in the body
zinc transport
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Summary:Zinc deficiency is a common nutritional disorder with detrimental health consequences. Whether parental zinc deficiency induces intergenerational effects remains largely unknown. We investigated the effects of a combined maternal and paternal zinc deficiency on offspring's metabolic outcomes and gene expression changes in . The parent flies were raised on zinc-deficient diets throughout development, and their progeny were assessed. Offspring from zinc-deprived parents exhibited a significant ( < 0.05) increase in body weight and whole-body zinc levels. They also displayed disrupted glucose metabolism, altered lipid homeostasis, and diminished activity of antioxidant enzymes. Gene expression analysis revealed significant ( < 0.05) alterations in zinc transport genes, with increases in mRNA levels of and for female and male offspring, respectively. Both sexes exhibited reduced mRNA levels and significant ( < 0.05) increases in the mRNA levels of and proinflammatory markers, and Overall, female offspring showed higher sensitivity to parental zinc deficiency. Our findings underscore zinc's crucial role in maintaining health and the gender-specific responses to zinc deficiency. There is the need for further exploration of the underlying mechanisms behind these intergenerational effects.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology13060401