Can chlorhexidine mouthwash twice daily ameliorate cyclosporine-induced gingival overgrowth?

Background/Purpose Gingival overgrowth can be induced in patients treated with cyclosporine-A (CsA), an immunosuppressant often used following organ transplantation. A pre-existing rat model designed to mimic CsA-induced gingival overgrowth in humans was used to test the effectiveness of frequent ap...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Formosan Medical Association 2013-03, Vol.112 (3), p.131-137
Main Authors: Gau, Ching-Hwa, Tu, Hsiao-Pei, Chin, Yu-Tang, Chen, Rebecca Y.A, Fu, Martin Ming-Jen, Fu, Earl
Format: Article
Language:English
Subjects:
Animals
chlorhexidine
Chlorhexidine - administration & dosage
cyclosporine
Cyclosporine - adverse effects
Gingival Hyperplasia - drug therapy
Gingival Hyperplasia - pathology
gingival overgrowth
Immunosuppressive Agents - adverse effects
Internal Medicine
Male
mouthwash
Mouthwashes - administration & dosage
Rats
Rats, Sprague-Dawley
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background/Purpose Gingival overgrowth can be induced in patients treated with cyclosporine-A (CsA), an immunosuppressant often used following organ transplantation. A pre-existing rat model designed to mimic CsA-induced gingival overgrowth in humans was used to test the effectiveness of frequent application of a chlorhexidine antiplaque solution in reducing the overgrowth. Methods Four groups of rats were fed CsA. One group received chlorhexidine mouthwash twice a day, the second group received chlorhexidine mouthwash once a day, the third group received chlorhexidine mouthwash every other day, and the fourth group did not receive chlorhexidine mouthwash all. A fifth negative control group received only mineral oil. Overgrowth was determined by measuring the changes in the gingival probing depth and the keratinized gingival widthon molars. A gingival histological examination was performed. Results Rats treated with mouthwash twice daily exhibited decreased probing depths and gingival widths without statistical significance. Histological examination revealed that CsA treatment caused gingival enlargement, whereas chlorhexidine treatment twice a day diminished the enlargement. Conclusion These findings suggest that chlorhexidine mouthwash used twice daily may reduce the severity of CsA-induced gingival overgrowth. Further research is warranted to determine the optimal dose and treatment regimen.
ISSN:0929-6646
DOI:10.1016/j.jfma.2011.12.004