Cigarette smoking is associated with high level of ferroptosis in seminal plasma and affects semen quality

The effects of cigarette smoking on male semen quality are controversial, and the molecular mechanisms underlying how cigarette smoking affects semen quality are not clear yet. In this study, semen samples from 70 heavy smokers and 75 non-smokers receiving infertility treatment were included. Basic...

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Bibliographic Details
Published in:Reproductive biology and endocrinology 2020-05, Vol.18 (1), p.55-8, Article 55
Main Authors: Ou, Zhanhui, Wen, Qirong, Deng, Yu, Yu, Yang, Chen, Zhiheng, Sun, Ling
Format: Article
Language:English
Subjects:
Adult
Apoptosis
Case-Control Studies
Cells, Cultured
China
Cigarette smoke
Cigarette smoke condensate
Cigarette smoking
Cigarette Smoking - adverse effects
Cigarettes
Ferroptosis
Ferroptosis - drug effects
Ferroptosis - physiology
Glutathione
Glutathione - metabolism
Humans
Infertility
Infertility, Male - etiology
Infertility, Male - metabolism
Infertility, Male - pathology
Iron
Lipid peroxidation
Lipids
Male
Molecular modelling
Morphology
Motility
Nicotiana - adverse effects
Peroxidase
Plasma
Proteins
Quality
Reactive oxygen species
Reactive Oxygen Species - metabolism
Semen
Semen - drug effects
Semen - metabolism
Semen - physiology
Semen Analysis
Semen quality
Smoke - adverse effects
Smokers
Smoking
Sperm
Sperm Motility - drug effects
Spermatogenesis
Spermatozoa - drug effects
Spermatozoa - physiology
Studies
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Summary:The effects of cigarette smoking on male semen quality are controversial, and the molecular mechanisms underlying how cigarette smoking affects semen quality are not clear yet. In this study, semen samples from 70 heavy smokers and 75 non-smokers receiving infertility treatment were included. Basic semen parameters in non-smokers and heavy smokers were evaluated. Levels of glutathione (GSH), lipid reactive oxygen species (ROS), iron and GSH-dependent peroxidase 4 (GPX4) protein level were observed in human seminal plasma and in GC-2Spd cells exposed to cigarette smoke condensate (CSC). Heavy smokers had significantly higher abnormalities (sperm viability and sperm progressive motility) than non-smoking counterparts. Comparing non-smokers group, GSH level was reduced in the group of heavy smokers (P 
ISSN:1477-7827
1477-7827
DOI:10.1186/s12958-020-00615-x