Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix

Severe Acute Respiratory Syndrome Coronavirus 2 is the third highly pathogenic human coronavirus in history. Since the emergence in Hubei province, China, during late 2019, the situation evolved to pandemic level. Following China, Europe was the second epicenter of the pandemic. To better comprehend...

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Bibliographic Details
Published in:Viruses 2020-12, Vol.12 (12), p.1401
Main Authors: Kemenesi, Gábor, Zeghbib, Safia, Somogyi, Balázs A, Tóth, Gábor Endre, Bányai, Krisztián, Solymosi, Norbert, Szabo, Peter M, Szabó, István, Bálint, Ádám, Urbán, Péter, Herczeg, Róbert, Gyenesei, Attila, Nagy, Ágnes, Pereszlényi, Csaba István, Babinszky, Gergely Csaba, Dudás, Gábor, Terhes, Gabriella, Zöldi, Viktor, Lovas, Róbert, Tenczer, Szabolcs, Kornya, László, Jakab, Ferenc
Format: Article
Language:English
Subjects:
China - epidemiology
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - virology
Data analysis
Disease Outbreaks
Disease transmission
Epidemics
Epidemiology
Europe - epidemiology
Europe, Eastern - epidemiology
Gene Regulatory Networks
Genome, Viral
Genomes
Growth models
Haplotypes
human coronavirus
Humans
Hungary - epidemiology
Laboratories
network analysis
Oropharynx - virology
outbreak
pandemic
Pandemics
phylodynamics
Phylogenetics
Phylogeny
RNA, Viral - genetics
SARS-CoV-2
SARS-CoV-2 - genetics
SARS-CoV-2 - isolation & purification
Sequence Analysis, DNA
Severe acute respiratory syndrome coronavirus 2
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Summary:Severe Acute Respiratory Syndrome Coronavirus 2 is the third highly pathogenic human coronavirus in history. Since the emergence in Hubei province, China, during late 2019, the situation evolved to pandemic level. Following China, Europe was the second epicenter of the pandemic. To better comprehend the detailed founder mechanisms of the epidemic evolution in Central-Eastern Europe, particularly in Hungary, we determined the full-length SARS-CoV-2 genomes from 32 clinical samples collected from laboratory confirmed COVID-19 patients over the first month of disease in Hungary. We applied a haplotype network analysis on all available complete genomic sequences of SARS-CoV-2 from GISAID database as of 21 April 2020. We performed additional phylogenetic and phylogeographic analyses to achieve the recognition of multiple and parallel introductory events into our region. Here, we present a publicly available network imaging of the worldwide haplotype relations of SARS-CoV-2 sequences and conclude the founder mechanisms of the outbreak in Central-Eastern Europe.
ISSN:1999-4915
1999-4915
DOI:10.3390/v12121401