Germ cells in the teleost fish medaka have an inherent feminizing effect

Germ cells are the only cells that can transfer genetic materials to the next generation via the sperm or egg. However, recent analyses in teleosts revealed another essential role of germ cells: feminizing the gonads. In our study, medaka mutants in which gametogenesis was blocked at specific stages...

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Bibliographic Details
Published in:PLoS genetics 2018-03, Vol.14 (3), p.e1007259-e1007259
Main Authors: Nishimura, Toshiya, Yamada, Kazuki, Fujimori, Chika, Kikuchi, Mariko, Kawasaki, Toshihiro, Siegfried, Kellee R, Sakai, Noriyoshi, Tanaka, Minoru
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Developmental genetics
Dimorphism (Biology)
Engineering and technology
Feminization
Genetic aspects
Genetic research
Germ cells
Japanese rice fish
Medicine and Health Sciences
Physiological aspects
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Summary:Germ cells are the only cells that can transfer genetic materials to the next generation via the sperm or egg. However, recent analyses in teleosts revealed another essential role of germ cells: feminizing the gonads. In our study, medaka mutants in which gametogenesis was blocked at specific stages provides the novel view that the feminizing effect of germ cells occurs in parallel with other reproductive elements, such as meiosis, the sexual fate decision of germ cells, and gametogenesis. Germ cells in medaka may have a potential to feminize gonads at the moment they have developed.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1007259