Immune responses to P falciparum antibodies in symptomatic malaria patients with variant hemoglobin genotypes in Ghana

Haemoglobin (Hb) variants such as sickle cell trait (SCT/HbAS) play a role in protecting against clinical malaria, but little is known about the development of immune responses against malaria parasite (Plasmodium falciparum surface protein 230 (Pfs230) and Plasmodium falciparum erythrocyte binding...

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Bibliographic Details
Published in:BMC immunology 2024-02, Vol.25 (1), p.14-14, Article 14
Main Authors: Asare, Kwame Kumi, Agrah, Benjamin, Ofori-Acquah, Fiifi Solomon, Kudzi, William, Aryee, Nii Ayite, Amoah, Linda Eva
Format: Article
Language:English
Subjects:
Analysis
Antibodies
Antigens
Blood Group Antigens
Capillarys 2 flex piercing analyzer
Cellulose acetate
Control
Exocrine glands
Genotype
Genotype & phenotype
Genotypes
Ghana - epidemiology
Heamoglobin S and C
Hemoglobin
Hemoglobins - metabolism
Humans
Identification and classification
Immune response
Immunity
Immunoglobulin G
Malaria
Malaria, Falciparum - epidemiology
Microscopy
Parasites
Patients
Plasmodium falciparum
Prevention
Risk factors
Salivary gland
Salivary gland antigen
Serology
Sickle cell disease
Statistical significance
Symptomatic malaria
Vaccines
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Summary:Haemoglobin (Hb) variants such as sickle cell trait (SCT/HbAS) play a role in protecting against clinical malaria, but little is known about the development of immune responses against malaria parasite (Plasmodium falciparum surface protein 230 (Pfs230) and Plasmodium falciparum erythrocyte binding antigen 175 region-3 (PfEBA175-3R)) and vector (on the An. gambiae Salivary Gland Protein-6 peptide 1 (gSG6-P1)) antigens in individuals with variants Hb genotypes. This study assessed antibody (IgG) responses against malaria parasite, Pfs230 and PfEBA175-3R and vector, gSG6-P1 in febrile individuals with variant Hb genotypes. The study was conducted on symptomatic malaria patients attending various healthcare facilities throughout Ghana. Microscopy and ELISA were used to determine the natural IgG antibody levels of gSG6-P1, PfEBA175-3R & Pfs230, and Capillarys 2 Flex Piercing was used for Hb variants determination. Of the 600 symptomatic malaria patients, 50.0% of the participants had malaria parasites by microscopy. The majority 79.0% (398/504) of the participants had Hb AA, followed by HbAS variant at 11.3% (57/504) and HbAC 6.7% (34/504). There were significantly (p 
ISSN:1471-2172
1471-2172
DOI:10.1186/s12865-024-00607-1