Cancer and Thrombotic Risk: The Platelet Paradigm

Hematologic malignancies and solid tumors increase the risk of venous and arterial thrombosis and contribute greatly to patient morbidity and mortality. Thrombosis occurs when the intricate balance of circulating antithrombotic and prothrombotic blood elements are disrupted. In recent years, the int...

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Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2017-11, Vol.4, p.67-67
Main Authors: Lee, Elizabeth C, Cameron, Scott J
Format: Article
Language:English
Subjects:
antiocoagulation
cancer progression
Cardiovascular Medicine
dysregulated platelets
platelet activation
platelet dysfunction
thrombosis
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Summary:Hematologic malignancies and solid tumors increase the risk of venous and arterial thrombosis and contribute greatly to patient morbidity and mortality. Thrombosis occurs when the intricate balance of circulating antithrombotic and prothrombotic blood elements are disrupted. In recent years, the interplay between paraneoplastic cells and platelets has become apparent, with a change in platelet phenotype causing dysregulated platelet activity. This review discusses mechanism of thrombosis in cancer, evidence for using drug therapy, and exciting research efforts to understand and hopefully control aberrant thrombotic events in patients with cancer.
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2017.00067