Mast cells are responsible for the lack of anti-inflammatory effects of morphine in CBA mice

BACKGROUND and aim: Morphine co-injection has anti-inflammatory effects on zymosan-induced peritonitis in several strains of mice except that of CBA. As peritoneal mast cells (pMCs) are much more numerous in CBA mice than in SWISS mice, the role of pMCs in morphine-modulated zymosan peritonitis is c...

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Bibliographic Details
Published in:Mediators of Inflammation 2004-12, Vol.2004 (5-6), p.365-368
Main Authors: Stankiewicz, Elzbieta, Wypasek, Ewa, Plytycz, Barbara
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
C48/80
Cell Degranulation - drug effects
Histamine
Histamine Release - drug effects
In Vitro Techniques
Inflammation Mediators - metabolism
Male
Mast Cells - drug effects
Mast Cells - physiology
Mice
Mice, Inbred CBA
Morphine
Morphine - pharmacology
p-Methoxy-N-methylphenethylamine - pharmacology
Peritoneal inflammation
Peritoneal mast cells
Peritonitis - etiology
Peritonitis - physiopathology
Peritonitis - prevention & control
Species Specificity
Zymosan - toxicity
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Summary:BACKGROUND and aim: Morphine co-injection has anti-inflammatory effects on zymosan-induced peritonitis in several strains of mice except that of CBA. As peritoneal mast cells (pMCs) are much more numerous in CBA mice than in SWISS mice, the role of pMCs in morphine-modulated zymosan peritonitis is compared in CBA and SWISS males. Methods: pMCs were treated in vitro with morphine or C48/80 for comparison of histamine release. In vivo accumulation of leukocytes and histamine in peritoneal exudate were recorded after intraperitoneal injection with morphine, zymosan, or zymosan plus morphine. Results and conclusion: Morphine induces histamine release by pMCs from CBA mice but not SWISS mice. In vivo morphine-induced peritonitis is stronger in CBA mice than SWISS mice. Corollary, morphine antiinflammatory effects on zymosan peritonitis are reversed in CBA mice by its pro-inflammatory action through CBA pMCs.
ISSN:0962-9351
1466-1861
DOI:10.1080/09629350400008778