Characterization of Vascular Patterns Associated with Endothelial Glycocalyx Damage in Early- and Late-Onset Preeclampsia

This paper provides an assessment of molecular and functional changes in blood vessels, and a description of vascular patterns during preeclampsia (PE). Patients with normal pregnancy, and pregnancy complicated by PE at earlier (20–34 weeks) and later terms (≥34 weeks) underwent a 24 h monitoring of...

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Bibliographic Details
Published in:Biomedicines 2022-11, Vol.10 (11), p.2790
Main Authors: Ziganshina, Marina M, Muminova, Kamilla T, Khasbiullina, Nailia R, Khodzhaeva, Zulfiya S, Yarotskaya, Ekaterina L, Sukhikh, Gennady T
Format: Article
Language:English
Subjects:
Abdomen
Age
Blood levels
Blood pressure
Blood vessels
BPLab 24 h blood pressure monitoring
Coronary vessels
Disease
early-onset preeclampsia
endothelial glycocalyx
Heart
Hemodynamics
Heparan sulfate
Hyaluronic acid
Hypertrophy
late-onset preeclampsia
Myocardium
Pathogenesis
Physiological aspects
Pre-eclampsia
Preeclampsia
Pregnancy
Proteoglycans
Statistical analysis
Syndecan
Ultrasonic imaging
vascular patterns
Veins & arteries
Velocity
Ventricle
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Summary:This paper provides an assessment of molecular and functional changes in blood vessels, and a description of vascular patterns during preeclampsia (PE). Patients with normal pregnancy, and pregnancy complicated by PE at earlier (20–34 weeks) and later terms (≥34 weeks) underwent a 24 h monitoring of blood pressure, central hemodynamics, arterial stiffness, and myocardial function. The blood levels of the structural components of endothelial glycocalyx (eGC): syndecan-1 (SDC 1), heparan sulfate proteoglycan 2 (HSPG2), and hyaluronic acid (HA) were determined. In early-onset PE, the vascular pattern comprised changes in all structural components of eGCs, including transmembrane proteoglycans levels, and severe disorders of central hemodynamics, arterial stiffness, and myocardial changes, probably leading to more severe course of PE and the formation of morphological grounds for cardiovascular disorders. The vascular pattern in late-onset PE, including changes in HA levels, central hemodynamics, and myocardial function, may be a signal of potential cardiovascular disorder. PE may change adaptive hemodynamic responses to a pathological reaction affecting both arterial elasticity and the left ventricular myocardium, with its subsequent hypertrophy and decompensation, leading to a delayed development of cardiovascular disorders after PE. Further clinical studies of these indicators will possibly identify predictors of PE and long-term consequences of the disease.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10112790